Bączkowska Monika, Dutsch-Wicherek Magdalena Maria, Przytuła Ewa, Faryna Jan, Wojtyła Cezary, Ali Mohamed, Knafel Anna, Ciebiera Michał
Centre of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland.
Centre of Postgraduate Medical Education, Department of Psychiatry, 01-809 Warsaw, Poland.
Biomedicines. 2022 Apr 16;10(4):918. doi: 10.3390/biomedicines10040918.
B7 homolog 4 protein (B7-H4), a member of the B7 family, is a immunomodulatory membrane protein. The aim of the study was to evaluate the expression of this protein in the decidua and placental tissues in case of placental abruption (PA) compared to cases of retained placental tissue (RPT) and controls. Tissue samples were obtained from 47 patients with PA, 60 patients with RPT, and 41 healthy controls. The samples were stained for B7-H4 expression, analyzed by an expert pathologist, and a semi-quantitative scale was applied. A statistical analysis revealed that the expression of B7-H4 was significantly higher in the decidua in PA samples compared to samples from patients with RPT (p-value < 0.001) and healthy controls (p-value < 0.001). The expression of B7-H4 in the placental chorionic villus was significantly higher in PA samples in relation to samples from healthy controls (p-value < 0.001) but not in relation to RPT samples (p-value = 0.0853). This finding suggests that B7-H4 might play an important role in mechanisms restoring reproductive tract homeostasis. Further research is necessary in regard to the role of B7-H4 in PA.
B7 同源物4蛋白（B7-H4）是B7家族的一员，是一种免疫调节性膜蛋白。本研究的目的是评估与胎盘组织残留（RPT）病例及对照相比，胎盘早剥（PA）病例中该蛋白在蜕膜和胎盘组织中的表达情况。从47例PA患者、60例RPT患者和41例健康对照中获取组织样本。对样本进行B7-H4表达染色，由专业病理学家进行分析，并应用半定量量表。统计分析显示，与RPT患者样本（p值<0.001）和健康对照（p值<0.001）相比，PA样本中蜕膜的B7-H4表达显著更高。与健康对照样本相比，PA样本中胎盘绒毛膜的B7-H4表达显著更高（p值<0.001），但与RPT样本相比则无显著差异（p值 = 0.0853）。这一发现表明，B7-H4可能在恢复生殖道内环境稳定的机制中发挥重要作用。关于B7-H4在PA中的作用，还需要进一步研究。
