[凋亡抑制基因Livin在膀胱移行细胞癌中的表达及其临床意义]

[Expression of apoptosis inhibitor gene Livin in bladder transitional cell carcinoma and clinical implication thereof].

作者信息

Song Tao, Hong Bao-fa, Gao Jiang-ping, Cai Wei, Wang Chun-yang

机构信息

Department of Urology, General Hospital of PLA, Beijing 100853, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2007 Mar 27;87(12):806-7.

PMID:17565859

Abstract

OBJECTIVE

To study the expression of Livin, an apoptosis inhibitor gene, in bladder transitional cell carcinoma (TCC), and to investigate its clinical and pathological implications.

METHODS

Reverse Transcription-Polymerase Chain Reaction (RT-PCR) was used to detect the expression of Livin in the tissues of TCC, 21 among them being recurrent carcinoma, obtained during operation from 60 cases, 48 males and 12 females, aged 58.6 (34 approximately 85), and 10 samples of tissues far from the TCC from the 60 cases.

RESULTS

The overall positive rate of Livin in the 60 cases of TCC was 28.3% (17/60), and was 0 in the 10 cases of tissues far from the TCC. The Livin positivity was not correlated with tumor stage and grade (both P > 0.05). The positive rate of the recurrent bladder carcinoma was 38.1% (8/21), higher than that of the primary bladder carcinoma (23.1%, 9/39), however, not significantly (P > 0.05).

CONCLUSION

Livin may play an essential role in bladder carcinogenesis and serve as a marker for prognosis of bladder carcinoma.

摘要

目的

研究凋亡抑制基因Livin在膀胱移行细胞癌（TCC）中的表达，并探讨其临床和病理意义。

方法

采用逆转录-聚合酶链反应（RT-PCR）检测60例手术切除的TCC组织（其中21例为复发性癌）中Livin的表达，患者年龄58.6岁（34至85岁），男性48例，女性12例，同时检测60例患者远离TCC的10份组织样本。

结果

60例TCC患者中Livin的总体阳性率为28.3%（17/60），10例远离TCC的组织样本中Livin阳性率为0。Livin阳性与肿瘤分期和分级均无相关性（P均>0.05）。复发性膀胱癌的阳性率为38.1%（8/21），高于原发性膀胱癌（23.1%，9/39），但差异无统计学意义（P>0.05）。