[环氧化酶-2在膀胱移行细胞癌中的表达及其意义]
[Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof].
作者信息
Yu Lei, Chen Xiao-jiang, Shi Pei-qing, Ding Qiang, Sun Chang-hua, Liu Guo-bin, Shi Dong-min, Huang Yong-gang
机构信息
Department of Urology, First Hospital of Harbin, Harbin 150010, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2008 Oct 21;88(38):2683-4.
OBJECTIVE
To study the expression of cyclooxygenase-2 (COX-2) in bladder transitional cell carcinoma (Tcc) and the clinical significance thereof.
METHODS
Immunohistochemistry was used to detect the expression of COX-2 in 56 specimens of bladder Tcc and 10 specimens of normal bladder tissue, all resected during operation.
RESULTS
No expression of COX-2 was detected in the 10 specimens of normal bladder tissue and in the 56 specimens of bladder Tcc the positive rate of COX-2 was 55.36%. The expression of COX-2 in bladder Tcc was closely correlated with the grade and stage of tumor (both P < 0.01).
CONCLUSION
COX-2 expression in bladder Tcc is closely correlated with the grade and stage.
目的
研究环氧化酶-2（COX-2）在膀胱移行细胞癌（Tcc）中的表达及其临床意义。
方法
采用免疫组织化学法检测56例膀胱Tcc手术切除标本及10例正常膀胱组织标本中COX-2的表达。
结果
10例正常膀胱组织标本中未检测到COX-2表达，56例膀胱Tcc标本中COX-2阳性率为55.36%。膀胱Tcc中COX-2的表达与肿瘤分级和分期密切相关（均P < 0.01）。
结论
膀胱Tcc中COX-2表达与分级和分期密切相关。
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