Togashi K, Kameya T, Ando K, Marumo F, Kawakami M
Department of Molecular Biology, Kitasato University School of Medicine, Tokyo, Japan.
Clin Chim Acta. 1991 Sep 30;201(3):193-200. doi: 10.1016/0009-8981(91)90370-r.
In cases of heart failure, the plasma level of immunoreactive human brain natriuretic peptide (IR-hBNP) measured by radioimmunoassay increased 6- to 46-fold over normal level (4.1 +/- 1.0 pg/ml), depending upon the severity. These levels did not significantly correlate to the levels of IR-human atrial natriuretic peptide in individuals. A 4-kDa IR-hBNP, corresponding to authentic hBNP (1-32), was predominant in normal plasma. In cases of cardiac disease, larger molecules which were assumed to be precursors of the 4-kDa form were accumulated in plasma. IR-hBNP was detected in spinal cords (7-24 pg/mg protein) and cerebrospinal fluid (8-19 pg/ml) of patients with noncardiac diseases. The major molecular form corresponded to the hBNP (1-32).
在心力衰竭病例中，通过放射免疫测定法测得的免疫反应性人脑利钠肽（IR-hBNP）血浆水平比正常水平（4.1±1.0 pg/ml）升高了6至46倍，具体倍数取决于严重程度。这些水平与个体中IR-人心房利钠肽的水平无显著相关性。一种与天然hBNP（1-32）相对应的4 kDa IR-hBNP在正常血浆中占主导地位。在心脏疾病病例中，假定为4 kDa形式前体的较大分子在血浆中积累。在非心脏疾病患者的脊髓（7-24 pg/mg蛋白质）和脑脊液（8-19 pg/ml）中检测到了IR-hBNP。主要分子形式与hBNP（1-32）相对应。
