Togashi K, Kameya T, Ando K, Marumo F, Kawakami M
Department of Molecular Biology, Kitasato University School of Medicine, Sagamihara.
Rinsho Byori. 1991 Jul;39(7):781-5.
By using a specific radioimmunoassay (RIA) for human brain natriuretic peptide (hBNP), we measured immunoreactive hBNP (ir-hBNP) in plasma from patients with congestive heart failure (CHF). There appeared to be relationship between the enhanced ir-hBNP secretory activity and the severity of the failing heart as well as that of immunoreactive human atrial natriuretic peptide (ir-hANP). However, the secretion of ir-hBNP was augmented much more than that of ir-hANP in sever CHF patients. Gel permeation chromatography coupled with the RIA revealed that ir-hBNP in human ventricle is composed with gamma-hBNP and hBNP (1-32) as well as that of human atrium. However, we found differences of the gamma-hBNP/hBNP (1-32) ratio in atrial and ventricular tissues. These findings suggest that the hBNP secretion mechanism differ in the two areas of human heart.
通过使用针对人脑钠肽（hBNP）的特定放射免疫分析（RIA），我们测量了充血性心力衰竭（CHF）患者血浆中的免疫反应性hBNP（ir-hBNP）。ir-hBNP分泌活性增强与心脏衰竭的严重程度以及免疫反应性人心房钠肽（ir-hANP）之间似乎存在关联。然而，在重度CHF患者中，ir-hBNP的分泌比ir-hANP增加得更多。凝胶渗透色谱结合RIA显示，人心室中的ir-hBNP与γ-hBNP和hBNP（1-32）组成，与人心房中的情况相同。然而，我们发现心房和心室组织中γ-hBNP/hBNP（1-32）的比例存在差异。这些发现表明，hBNP在人心脏的两个区域分泌机制不同。
