Krigsman Kristin, Nilsson J Lars G, Ring Lena
Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Pharmacoepidemiol Drug Saf. 2007 Oct;16(10):1120-8. doi: 10.1002/pds.1433.
To investigate whether patients with drugs for two chronic diseases, type 2 diabetes and asthma/chronic obstructive pulmonary diseases (COPD), showed the same refill adherence pattern in relation to their drug treatments during a 3-year period.
Patients 50 years and older who had been dispensed diabetes and asthma/COPD drugs in the county of Jämtland during 2001-2003 were included. The refill adherence was calculated based either on prescribed dosage or defined daily dose (DDD). A patient profile graph for each patient was constructed including the date of each dispensation and the time period covered by the dispensed drugs. For each patient, the dispensation pattern and the treatment persistency over time were determined.
In total, 56 patients were included in the study. Satisfactory refill adherence was found for 68% of the repeat prescriptions for diabetes drugs and for 42% of the repeat prescriptions for asthma/COPD drugs. About half (52%; 29/56) of the patients showed the same dispensation patterns for both diabetes and asthma/COPD drugs, and 86% (25/29) of these patients had a satisfactory refill adherence. However, there was no correlation or agreement regarding the dispensation patterns for diabetes and asthma/COPD drugs.
Patients showed higher refill adherence for their diabetes drugs than their asthma/COPD drugs. Our hypothesis that patients with satisfactory refill adherence to antihyperglycaemic drugs would also have satisfactory refill adherence to asthma/COPD drugs, was not supported.
调查患有2型糖尿病和哮喘/慢性阻塞性肺疾病（COPD）这两种慢性病的患者在3年期间内，其药物治疗的再配药依从模式是否相同。
纳入2001年至2003年期间在耶姆特兰县领取糖尿病和哮喘/COPD药物的50岁及以上患者。再配药依从性根据规定剂量或限定日剂量（DDD）计算。为每位患者绘制一份用药记录图，包括每次配药日期和所配药物覆盖的时间段。确定每位患者的配药模式和随时间的治疗持续性。
该研究共纳入56名患者。糖尿病药物重复处方的再配药依从性良好率为68%，哮喘/COPD药物重复处方的再配药依从性良好率为42%。约一半（52%；29/56）的患者糖尿病和哮喘/COPD药物的配药模式相同，其中86%（25/29）的患者再配药依从性良好。然而，糖尿病和哮喘/COPD药物的配药模式之间没有相关性或一致性。
患者对糖尿病药物的再配药依从性高于哮喘/COPD药物。我们关于对抗高血糖药物再配药依从性良好的患者对哮喘/COPD药物也有良好再配药依从性的假设未得到支持。
