Su Kang-Cheng, Lay Shinn-Liang, Perng Reury-Perng, Chang Shi-Chuan, Chen Yuh-Min
Chest Department, Taipei-Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan.
Lung Cancer. 2007 Oct;58(1):144-8. doi: 10.1016/j.lungcan.2007.04.012. Epub 2007 Jun 13.
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by an accumulation of periodic acid-Schiff (PAS) positive lipoproteinaceous material in the alveolar space. It is usually idiopathic, and secondary to hematologic malignancy or some atypical infection. To date, there are only five published case reports of PAP occurring in association with solid organ cancer. We herein report two cases of PAP associated with lung cancer: one, a case of idiopathic PAP with subsequent development of lung cancer, and the other, a case of coexisting lung cancer and PAP. In conclusion, PAP can occur prior to or coincidently with lung cancer.
肺泡蛋白沉积症（PAP）是一种罕见疾病，其特征为肺泡腔内存在过碘酸-雪夫（PAS）阳性的脂蛋白样物质积聚。该病通常为特发性，继发于血液系统恶性肿瘤或某些非典型感染。迄今为止，仅有五例关于PAP与实体器官癌相关的病例报告发表。我们在此报告两例与肺癌相关的PAP病例：一例为特发性PAP随后发生肺癌，另一例为肺癌与PAP并存。总之，PAP可在肺癌之前或与之同时发生。
