Campbell Adam M, Park Collin R, Zoladz Phillip R, Muñoz Carmen, Fleshner Monika, Diamond David M
Medical Research, VA Hospital, 13000 Bruce B. Downs Blvd., Tampa, FL, USA.
Eur Neuropsychopharmacol. 2008 Feb;18(2):87-98. doi: 10.1016/j.euroneuro.2007.04.004. Epub 2007 Jun 13.
Extensive research has shown that the antidepressant tianeptine blocks the adverse effects of chronic stress on hippocampal functioning. The current series of experiments extended this area of investigation by examining the influence of tianeptine on acute stress-induced impairments of spatial (hippocampus-dependent) memory. Tianeptine (10 mg/kg, ip) administered to adult male rats before, but not after, water maze training blocked the amnestic effects of predator stress (occurring between training and retrieval) on memory. The protective effects of tianeptine on memory occurred in rats which had extensive pre-stress training, as well as in rats which had only a single day of training. Tianeptine blocked stress effects on memory without altering the stress-induced increase in corticosterone levels. Propranolol, a beta-adrenergic receptor antagonist (5 and 10 mg/kg, ip), in contrast, did not block stress-induced amnesia. These findings indicate that treatment with tianeptine, unlike propanolol, provides an effective means with which to block the adverse effects of stress on cognitive functions of the hippocampus.
广泛的研究表明，抗抑郁药噻奈普汀可阻断慢性应激对海马功能的不利影响。当前这一系列实验通过研究噻奈普汀对急性应激诱导的空间（依赖海马）记忆损伤的影响，扩展了这一研究领域。在水迷宫训练前而非训练后给成年雄性大鼠腹腔注射噻奈普汀（10毫克/千克），可阻断捕食者应激（发生在训练和记忆提取之间）对记忆的遗忘作用。噻奈普汀对记忆的保护作用在有大量应激前训练的大鼠以及仅训练一天的大鼠中均有出现。噻奈普汀可阻断应激对记忆的影响，而不改变应激诱导的皮质酮水平升高。相比之下，β-肾上腺素能受体拮抗剂普萘洛尔（5和10毫克/千克，腹腔注射）并未阻断应激诱导的失忆。这些发现表明，与普萘洛尔不同，噻奈普汀治疗提供了一种有效手段来阻断应激对海马认知功能的不利影响。
