• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.用于结核分枝杆菌阿拉伯糖基转移酶抑制活性的对称C-连接和假对称O-连接二糖类似物的合成。
Bioorg Med Chem Lett. 2007 Aug 15;17(16):4527-30. doi: 10.1016/j.bmcl.2007.05.099. Epub 2007 Jun 6.
2
Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity.
Bioorg Med Chem. 2002 Apr;10(4):923-8. doi: 10.1016/s0968-0896(01)00343-1.
3
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.作为结核分枝杆菌阿拉伯糖基转移酶底物和抑制剂的脱氧α(1→5)连接阿拉伯呋喃糖二糖的合成
Bioorg Med Chem. 2009 Jan 15;17(2):872-81. doi: 10.1016/j.bmc.2008.11.027. Epub 2008 Nov 18.
4
Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.关于α(1→5)连接的辛基阿拉伯呋喃糖二糖对分枝杆菌阿拉伯糖基转移酶活性的研究。
Bioorg Med Chem. 2001 Dec;9(12):3145-51. doi: 10.1016/s0968-0896(01)00180-8.
5
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
Bioorg Med Chem Lett. 2002 Oct 7;12(19):2749-52. doi: 10.1016/s0960-894x(02)00536-x.
6
Studies on (beta,1-->5) and (beta,1-->6) linked octyl Gal(f) disaccharides as substrates for mycobacterial galactosyltransferase activity.
Bioorg Med Chem. 2001 Dec;9(12):3129-43. doi: 10.1016/s0968-0896(01)00179-1.
7
Studies on beta-D-Gal(f)-(1-->4)-alpha-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activity.
Bioorg Med Chem. 1999 Nov;7(11):2407-13. doi: 10.1016/s0968-0896(99)00199-6.
8
Synthetic analogues of mycobacterial arabinogalactan linkage-disaccharide part II: synthesis and preliminary screening of lipophilic O-alkyl glycosides.分枝杆菌阿拉伯半乳聚糖连接二糖的合成类似物 Ⅱ：亲脂性 O-烷基糖苷的合成和初步筛选。
Carbohydr Res. 2011 Nov 8;346(15):2401-5. doi: 10.1016/j.carres.2011.08.027. Epub 2011 Sep 1.
9
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis.二糖类似物作为结核分枝杆菌中糖基转移酶的探针
Bioorg Med Chem. 2007 Aug 15;15(16):5629-50. doi: 10.1016/j.bmc.2007.04.012. Epub 2007 Apr 10.
10
Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgE.结核分枝杆菌GlgE的基于聚羟基吡咯烷的抑制剂的合成。
J Org Chem. 2014 Oct 17;79(20):9444-50. doi: 10.1021/jo501481r. Epub 2014 Aug 26.

引用本文的文献

1
A minimalistic approach to develop new anti-apicomplexa polyamines analogs.一种开发新型抗顶复门原虫多胺类似物的简约方法。
Eur J Med Chem. 2018 Jan 1;143:866-880. doi: 10.1016/j.ejmech.2017.11.069. Epub 2017 Dec 2.
2
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.作为结核分枝杆菌阿拉伯糖基转移酶底物和抑制剂的脱氧α(1→5)连接阿拉伯呋喃糖二糖的合成
Bioorg Med Chem. 2009 Jan 15;17(2):872-81. doi: 10.1016/j.bmc.2008.11.027. Epub 2008 Nov 18.

本文引用的文献

1
Synthesis of oligosaccharides as potential inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-5 modified arabinofuranosyl residues.作为分枝杆菌阿拉伯糖基转移酶潜在抑制剂的寡糖合成。含有C-5修饰阿拉伯呋喃糖基残基的二糖和三糖。
Carbohydr Res. 2004 Mar 15;339(4):853-65. doi: 10.1016/j.carres.2003.12.015.
2
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
Bioorg Med Chem Lett. 2002 Oct 7;12(19):2749-52. doi: 10.1016/s0960-894x(02)00536-x.
3
Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.关于α(1→5)连接的辛基阿拉伯呋喃糖二糖对分枝杆菌阿拉伯糖基转移酶活性的研究。
Bioorg Med Chem. 2001 Dec;9(12):3145-51. doi: 10.1016/s0968-0896(01)00180-8.
4
Synthesis of alpha- and beta-D-(1-->6)-C-Disaccharides by Wittig Olefination of Formyl C-Glycosides with Glycopyranose 6-Phosphoranes.通过甲酰基 C-糖苷与吡喃葡萄糖 6-膦叶立德的维蒂希烯烃化反应合成α-和β-D-(1→6)-C-二糖
J Org Chem. 1997 Nov 14;62(23):8114-8124. doi: 10.1021/jo971177n.
5
Synthesis of disaccharides related to the mycobacterial arabinogalactan.与分枝杆菌阿拉伯半乳聚糖相关的二糖的合成。
Carbohydr Lett. 2001;4(2):117-22.
6
Unexpected formation of glycals upon attempted C-alkylation of protected glycosylacetylenes.在对受保护的糖基乙炔进行C-烷基化尝试时意外形成了糖烯。
Carbohydr Res. 2000 Feb 25;324(3):210-7. doi: 10.1016/s0008-6215(99)00296-7.
7
Ethambutol-sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis.乙胺丁醇-糖杂合物作为分枝杆菌细胞壁生物合成的潜在抑制剂。
Carbohydr Res. 1999 Apr 30;317(1-4):164-79. doi: 10.1016/s0008-6215(99)00069-5.
8
Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase.结核分枝杆菌和鸟分枝杆菌复合群对亲脂性脱氮蝶啶衍生物（二氢叶酸还原酶抑制剂）的敏感性。
J Antimicrob Chemother. 1998 Dec;42(6):811-5. doi: 10.1093/jac/42.6.811.
9
The mycobacterial cell wall: structure, biosynthesis and sites of drug action.分枝杆菌细胞壁：结构、生物合成及药物作用位点
Curr Opin Chem Biol. 1997 Dec;1(4):579-88. doi: 10.1016/s1367-5931(97)80055-5.
10
Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay.分枝杆菌阿拉伯聚糖生物合成：在阿拉伯糖基转移测定法开发中使用合成阿拉伯糖苷受体。
Glycobiology. 1997 Dec;7(8):1121-8. doi: 10.1093/glycob/7.8.1121.

用于结核分枝杆菌阿拉伯糖基转移酶抑制活性的对称C-连接和假对称O-连接二糖类似物的合成。

Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.

作者信息

Pathak Ashish K, Pathak Vibha, Riordan James R, Suling William J, Gurcha Sudagar S, Besra Gurdyal S, Reynolds Robert C

机构信息

Drug Discovery Division, Southern Research Institute, PO Box 55305, Birmingham, AL 35255, USA.

出版信息

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4527-30. doi: 10.1016/j.bmcl.2007.05.099. Epub 2007 Jun 6.

DOI:10.1016/j.bmcl.2007.05.099
PMID:17566735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2699574/
Abstract

Herein we report the synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [14C]-DPA as the glycosyl donor is also presented. In addition, in vitro inhibitory activity for the disaccharides was determined in a colorimetric broth microdilution assay system against MTB H37Ra and Mycobacterium avium.

摘要

在此，我们报告了与结核分枝杆菌细胞壁中存在的阿拉伯糖基（Araf）基序结构相关的对称C-连接和假对称O-连接二糖的合成。还介绍了它们在以[14C]-DPA作为糖基供体的基于竞争的阿拉伯糖基转移酶测定中的活性。此外，在比色肉汤微量稀释测定系统中测定了二糖对结核分枝杆菌H37Ra和鸟分枝杆菌的体外抑制活性。