分枝杆菌阿拉伯半乳聚糖连接二糖的合成类似物 Ⅱ：亲脂性 O-烷基糖苷的合成和初步筛选。
Synthetic analogues of mycobacterial arabinogalactan linkage-disaccharide part II: synthesis and preliminary screening of lipophilic O-alkyl glycosides.
机构信息
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, India.
出版信息
Carbohydr Res. 2011 Nov 8;346(15):2401-5. doi: 10.1016/j.carres.2011.08.027. Epub 2011 Sep 1.
PMID:21962454
Abstract
Lipophilic analogues of the linkage-disaccharide found in the mycobacterial cell wall were synthesized and the synthetic analogues when biologically evaluated showed promising antimycobacterial property with MIC value in the range 3.13-12.50 μg/mL against Mycobacterium tuberculosis H(37)Rv.
摘要
合成了分枝杆菌细胞壁中连接双糖的亲脂类似物，经生物评价，这些合成类似物具有良好的抗分枝杆菌活性，对结核分枝杆菌 H(37)Rv 的 MIC 值范围为 3.13-12.50 μg/mL。
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