Eggink Dirk, Melchers Mark, Sanders Rogier W
Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, The Netherlands.
Trends Microbiol. 2007 Jul;15(7):291-4. doi: 10.1016/j.tim.2007.05.006. Epub 2007 Jun 12.
HIV-1 evades antibody-mediated neutralization in many cunning ways. The recent structural characterization of a conserved neutralization epitope on the envelope glycoprotein complex (Env) provides clues to the vulnerabilities of the virus. We discuss these observations and explain their relevance for HIV-1 vaccine design.
HIV-1通过多种巧妙方式逃避抗体介导的中和作用。近期对包膜糖蛋白复合物（Env）上一个保守中和表位的结构表征为该病毒的脆弱性提供了线索。我们讨论了这些观察结果，并解释了它们与HIV-1疫苗设计的相关性。
