抗人免疫缺陷病毒1型抗体：瞄准正确靶点
Antibodies to HIV-1: aiming at the right target.
作者信息
Eggink Dirk, Melchers Mark, Sanders Rogier W
机构信息
Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, The Netherlands.
出版信息
Trends Microbiol. 2007 Jul;15(7):291-4. doi: 10.1016/j.tim.2007.05.006. Epub 2007 Jun 12.
HIV-1 evades antibody-mediated neutralization in many cunning ways. The recent structural characterization of a conserved neutralization epitope on the envelope glycoprotein complex (Env) provides clues to the vulnerabilities of the virus. We discuss these observations and explain their relevance for HIV-1 vaccine design.
HIV-1通过多种巧妙方式逃避抗体介导的中和作用。近期对包膜糖蛋白复合物（Env）上一个保守中和表位的结构表征为该病毒的脆弱性提供了线索。我们讨论了这些观察结果，并解释了它们与HIV-1疫苗设计的相关性。
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