抗结核药物乙胺丁醇构象受限类似物的合成与生物学评价
Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol.
作者信息
Faugeroux Vanessa, Génisson Yves, Salma Yahya, Constant Patricia, Baltas Michel
机构信息
Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068, Université Paul Sabatier, 31062 Toulouse, Cedex 9, France.
出版信息
Bioorg Med Chem. 2007 Sep 1;15(17):5866-76. doi: 10.1016/j.bmc.2007.05.064. Epub 2007 Jun 2.
PMID:17566744
Abstract
Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.
摘要
制备了三种抗结核药物乙胺丁醇的（S）-脯氨醇衍生的构象受限类似物，并对结核分枝杆菌进行了测试。
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