二茂铁基乙胺丁醇类似物和二茂铁基二胺的合成及其抗分枝杆菌活性
Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines.
作者信息
Razafimahefa Dorothée, Ralambomanana Dimby Andrianina, Hammouche Lies, Pélinski Lydie, Lauvagie Sylvia, Bebear Christiane, Brocard Jacques, Maugein Jeanne
机构信息
Laboratoire de Chimie Appliquée aux Substances Naturelles, Faculté des Sciences d'Antananarivo, B.P. 906, 101 Antananarivo, Madagascar.
出版信息
Bioorg Med Chem Lett. 2005 May 2;15(9):2301-3. doi: 10.1016/j.bmcl.2005.03.004.
PMID:15837313
Abstract
A new series of ferrocenyl diamino alcohols and diamines were synthesized and their inhibitory potencies were probed with Mycobacterium tuberculosis. Interestingly, ferrocenyl diamines 6a and b display significant activities against M. tuberculosis H37Rv.
摘要
合成了一系列新型二茂铁基二氨基醇和二胺，并检测了它们对结核分枝杆菌的抑制效力。有趣的是，二茂铁基二胺6a和6b对结核分枝杆菌H37Rv显示出显著活性。
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