Wysluch Andreas, Sommerer Florian, Ramadan Hamid, Loeffelbein Denys, Wolff Klaus-Dietrich, Hölzle Frank
Ruhr-Universität Bochum, Knappschaftskrankenhaus Bochum-Langendreer, Universitätsklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, In der Schornau 23-25, 44892 Bochum, Germany.
Mund Kiefer Gesichtschir. 2007 Aug;11(3):167-73. doi: 10.1007/s10006-007-0061-9.
Although parasitel infections in northern Europe are rare, it must be considered as differential diagnosis of malignant tumours of mucous membrane. With increasing tourisms in endemic areas, infections with parasite pathogen are spreading in non-endemic areas as well. In this case a mucous membrane malignancy with clinical feature of ulcer on unusual location was imitated. In this reported case the patient suffers with hepatitis c, causing cirrhosis of the liver and making a liver transplantation necessary. In this patient a history of a leishmaniosis which had been treated successful by the tropical institute is reported, but because of a new actually leishmaniosis-infection a liver transplantation is contraindicated. Under oral therapy with Miltefosin (IMPADIVO) a remission was successful. The leishmaniosis is a classical tropical disease. WHO reported a morbidity of nearly 12 million people in 88 countries around the world especially in tropical areas. Repeatedly infections in northern Europe caused by the phlebotonus-sandflies are described. Therefore leishmaniosis must be considered as differential diagnosis in suspect lesions of mucous membrane.
尽管北欧的寄生虫感染很少见，但在诊断黏膜恶性肿瘤时必须将其列为鉴别诊断之一。随着前往流行地区旅游人数的增加，寄生虫病原体感染也在非流行地区传播开来。在这种情况下，出现了具有不寻常部位溃疡临床特征的黏膜恶性肿瘤。在本报告病例中，患者患有丙型肝炎，导致肝硬化，因此需要进行肝移植。据报告，该患者曾患利什曼病，已由热带病研究所成功治愈，但由于新的利什曼病感染，肝移植被列为禁忌。在使用米替福新（IMPADIVO）进行口服治疗后病情缓解。利什曼病是一种典型的热带疾病。世界卫生组织报告称，全球88个国家（尤其是热带地区）约有1200万人患病。北欧也有多次因白蛉叮咬而感染的病例报告。因此，在怀疑黏膜病变时，必须将利什曼病列为鉴别诊断之一。
