Naidu M U, Ramesh Kumar T, Anuradha R T, Rao U R
Nizam's Institute of Medical Sciences, Hyderabad, India.
Drugs Exp Clin Res. 1991;17(5):271-5.
In an open study, thirty-five patients with active rheumatoid arthritis were treated with phenytoin. Various clinical and laboratory parameters showed good improvement after phenytoin. Early morning stiffness was significantly reduced after 8 weeks (p less than 0.05); pain index (p less than 0.001), articular index (p less than 0.01) and grip strength (p less than 0.01) showed significant improvement after 24 weeks. There was significant reduction in erythrocyte sedimentation rate (p less than 0.01). Except for three patients (skin rash in one and gastric irritation in two), all others tolerated phenytoin well. The results of the present study support the usefulness of phenytoin as a disease-modifying drug for rheumatoid arthritis.
在一项开放性研究中，35例活动性类风湿关节炎患者接受苯妥英治疗。苯妥英治疗后，各项临床和实验室指标均有明显改善。8周后，晨僵明显减轻（p<0.05）；24周后，疼痛指数（p<0.001）、关节指数（p<0.01）和握力（p<0.01）均有显著改善。红细胞沉降率显著降低（p<0.01）。除3例患者（1例出现皮疹，2例出现胃部刺激症状）外，其他患者对苯妥英耐受性良好。本研究结果支持苯妥英作为类风湿关节炎病情改善药物的有效性。
