Grindulis K A, Nichol F E, Oldham R
J Rheumatol. 1986 Dec;13(6):1035-9.
In a prospective open study, 18 patients with active rheumatoid arthritis were treated with phenytoin (300 mg/day) for 32 weeks. Clinical assessments improved significantly and there was no relapse 8 weeks after drug withdrawal. Serum C-reactive protein, plasma viscosity and hemoglobin also improved but changes were not significant. Serum phenytoin concentrations were lower than anticipated. Side effects were mild and caused 2 patients to withdraw. Our observations and the known effects of phenytoin on the immune system and collagen metabolism suggest that further controlled studies using higher doses are warranted.
在一项前瞻性开放性研究中，18例活动性类风湿关节炎患者接受苯妥英钠（300毫克/天）治疗32周。临床评估显著改善，停药8周后无复发。血清C反应蛋白、血浆黏度和血红蛋白也有所改善，但变化不显著。血清苯妥英钠浓度低于预期。副作用轻微，导致2例患者退出研究。我们的观察结果以及苯妥英钠对免疫系统和胶原代谢的已知作用表明，有必要使用更高剂量进行进一步的对照研究。
