翼齿六棱菊中的两种桉叶烷倍半萜。

Two eudesmane sesquiterpenes from Laggera pterodonta.

作者信息

Liu Y-B, Jia W, Yao Z, Pan Q, Takaishi Y, Duan H-Q

机构信息

R & D Centre of Zhongxin Pharmaceuticals Group Co. Ltd., Tianjin 300457, China.

出版信息

J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):233-7. doi: 10.1080/10286020600603924.

DOI:10.1080/10286020600603924

PMID:17566915

Abstract

Two new eudesmane sesquiterpenes, 2alpha-hydroxy pterodontic acid (1) and pterodolide [3alpha-(2-methyl-2,3-epoxy)-butyric-4alpha-acetoxy-8beta-ethoxy eudesma-7(11)-en-8alpha,12-olide (2), along with five known compounds (3-7) were isolated from the aerial parts of Laggera pterodonta. Their structures were elucidated on the basis of spectroscopic methods. The immunosuppressive activity of the isolated compounds was investigated.

摘要

从翼齿六棱菊地上部分分离得到两个新的桉叶烷倍半萜，2α-羟基翼齿酸（1）和翼齿内酯[3α-(2-甲基-2,3-环氧)-丁酸-4α-乙酰氧基-8β-乙氧基桉叶-7(11)-烯-8α,12-内酯（2），以及五个已知化合物（3 - 7）。通过光谱方法阐明了它们的结构。对分离得到的化合物的免疫抑制活性进行了研究。