Rozman J, Bartolić A, Ribaric S
ITIS d.o.o. Ljubljana, Center for Implantable Technology and Sensors, Ljubljana, Slovenia.
J Med Eng Technol. 2007 Jul-Aug;31(4):305-11. doi: 10.1080/03091900600992064.
Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system with tremor being one of its four main clinical features. Currently used methods can directly evaluate tremor amplitude and frequency but not joint movement in the affected limb. Measurement of joint movement facilitates the location of muscle groups that participate in PD tremor and this is important for treatment with local botulinum toxin injections. We developed and tested a method that measured tremor amplitude and frequency in a specific joint of the hand in PD patients. The tremor analysis method was based on force transducers adapted to record rest tremor of the wrist and metacarpophalangeal joints in two degrees of freedom for each joint. Direct measurements of joint movement in the hand can evaluate tremor amplitude and frequency and also locate the muscle groups that are most active in tremor movement, thus enabling their local treatment.
帕金森病（PD）是一种中枢神经系统的进行性退行性疾病，震颤是其四大主要临床特征之一。目前使用的方法可以直接评估震颤幅度和频率，但无法评估患肢的关节运动。关节运动的测量有助于确定参与帕金森病震颤的肌肉群位置，这对于局部注射肉毒杆菌毒素治疗很重要。我们开发并测试了一种测量帕金森病患者手部特定关节震颤幅度和频率的方法。该震颤分析方法基于力传感器，适用于记录每个关节在两个自由度下手腕和掌指关节的静止性震颤。直接测量手部关节运动可以评估震颤幅度和频率，还能确定震颤运动中最活跃的肌肉群，从而实现对其进行局部治疗。
