de Reuse Hilde, Bereswill Stefan
Institut Pasteur, Unité de Pathogénie Bacterienne des Muqueuses, Paris, France.
FEMS Immunol Med Microbiol. 2007 Jul;50(2):165-76. doi: 10.1111/j.1574-695X.2007.00244.x.
In this review, we summarize how genomic approaches contributed to the understanding of the biology of the recently discovered pathogen Helicobacter pylori. Comparative genomics provided new insights into H. pylori's spectacular genetic diversity and generated exiting hypotheses on its evolutionary history. Transcriptomic studies provided original information on the mechanisms of H. pylori gastric adaptation that are central to its virulence.
在本综述中，我们总结了基因组学方法如何有助于理解最近发现的病原体幽门螺杆菌的生物学特性。比较基因组学为幽门螺杆菌惊人的遗传多样性提供了新的见解，并就其进化历史提出了令人兴奋的假说。转录组学研究提供了关于幽门螺杆菌胃部适应性机制的原始信息，而这种适应性机制是其致病性的核心。
