儿童银屑病：对277名中国患者的研究。

Childhood psoriasis: a study of 277 patients from China.

作者信息

Fan X, Xiao F-L, Yang S, Liu J-B, Yan K-L, Liang Y-H, Sun L-D, Du W-H, Jin Y-T, Zhang X-J

机构信息

Institute of Dermatology, Anhui Medical University, Hefei, China.

出版信息

J Eur Acad Dermatol Venereol. 2007 Jul;21(6):762-5. doi: 10.1111/j.1468-3083.2007.02014.x.

DOI:10.1111/j.1468-3083.2007.02014.x

PMID:17567304

Abstract

OBJECTIVES

Psoriasis is common in childhood. The aim of this study was to present the clinical and epidemiological profile of childhood psoriasis in China.

METHODS

A total of 277 childhood psoriasis patients younger than 16 years old were enrolled. Statistical analysis and heritability were performed using EPI INFO 6.0, spss 10.0 and Falconer's method.

RESULTS

The median age was 11 years. The male : female ratio was 1:1.13. The median age of onset was 10 years. Of the patients, 48.7% had previous episodes of psoriasis. Of the 277 children with psoriasis, 68.6% had plaque-type psoriasis, 28.9% had guttate psoriasis, 1.1% presented pustular forms of psoriasis and 1.4% had erythroderma. The extensor surface of the extremities was the most frequently affected site in our patients, followed by the appearance of lesions on the scalp. A positive family history of psoriasis was found in 34.3% patients. The prevalence of psoriasis in first- and second-degree relatives was 7.0% and 1.0%, respectively. The heritability of psoriasis in first- and second-degree relatives was 72.67% and 55.18%, respectively.

CONCLUSION

Our epidemiologic studies offer the information about Han Chinese distribution, which provide clues to describe psoriasis in children.

摘要

目的

银屑病在儿童中很常见。本研究的目的是呈现中国儿童银屑病的临床和流行病学特征。

方法

共纳入277例16岁以下的儿童银屑病患者。使用EPI INFO 6.0、spss 10.0和Falconer方法进行统计分析和遗传度计算。

结果

中位年龄为11岁。男女比例为1:1.13。中位发病年龄为10岁。48.7%的患者既往有银屑病发作史。在277例银屑病患儿中，68.6%为斑块型银屑病，28.9%为点滴状银屑病，1.1%为脓疱型银屑病，1.4%为红皮病型银屑病。四肢伸侧是最常受累部位，其次是头皮出现皮损。34.3%的患者有银屑病家族史阳性。一级和二级亲属中银屑病的患病率分别为7.0%和1.0%。一级和二级亲属中银屑病的遗传度分别为72.67%和55.18%。