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邮寄尿液样本并非在年轻男性中筛查沙眼衣原体感染病例的有效方法。

Mailed urine samples are not an effective screening approach for Chlamydia trachomatis case finding among young men.

作者信息

Domeika M, Oscarsson L, Hallén A, Hjelm E, Sylvan S

机构信息

WHO Collaborating Centre for the Diagnosis and Research of Chlamydial and Other Reproductive Tract Infections, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

出版信息

J Eur Acad Dermatol Venereol. 2007 Jul;21(6):789-94. doi: 10.1111/j.1468-3083.2006.02088.x.

Abstract

BACKGROUND

Frequency of testing is known to be low for sexually transmitted infections (STIs) in men aged 20-24 years. The use of mailed, home-obtained urine specimens could increase the uptake of young men and facilitate screening programmes for the detection of asymptomatic Chlamydia trachomatis.

OBJECTIVE

The aim of the present study is to evaluate the home screening approach as a tool for recruitment of asymptomatic men for screening of genital C. trachomatis infections.

METHODS

Men aged 19-24 years old (n = 1936) were invited to participate in home-based testing for genital C. trachomatis infection. Persons who agreed to be tested were provided with a testing kit. Self-collected first void urine was sent for testing to the microbiology laboratory. The test result was accessible on the study's web-page 1 week after testing. Individuals with a diagnosed infection were instructed to contact the venereal disease department.

RESULTS

The response rate was 24% (462/1936). The responders' main reason for not participating was a feeling of being safe regarding STIs (87%; 159/182). The primary reason for this feeling of safety was that the responders were in a steady relationship (59%; 107/159). Having sex outside a steady relationship was reported by 36% (90/250) of the responders. The prevalence of C. trachomatis infection among the responders was 2.02% and the reported history of chlamydial infection was 36% (34/95). Out of the responders, 92% (229/249) were, to varying degrees, concerned about getting STIs; however, the majority (72%; 174/242) estimated the risk to be low.

CONCLUSION

Home screening using web-based answer management is a feasible tool for STI screening, which lowers the threshold for people at risk. In this particular population, however, the response rate was too low to be routinely introduced.

摘要

背景

已知20 - 24岁男性性传播感染(STIs)的检测频率较低。使用邮寄的、在家采集的尿液样本可能会提高年轻男性的参与度,并促进无症状沙眼衣原体检测的筛查项目。

目的

本研究的目的是评估家庭筛查方法作为招募无症状男性进行生殖器沙眼衣原体感染筛查工具的效果。

方法

邀请19 - 24岁的男性(n = 1936)参加基于家庭的生殖器沙眼衣原体感染检测。同意接受检测的人会收到一个检测试剂盒。自行采集的首次晨尿被送往微生物实验室进行检测。检测结果在检测后1周可在研究网页上查询。确诊感染的个体被指示联系性病科。

结果

响应率为24%(462/1936)。未参与者不参与的主要原因是自认为性传播感染风险低(87%;159/182)。这种安全感的主要原因是响应者处于稳定关系中(59%;107/159)。36%(90/250)的响应者报告有在稳定关系之外发生性行为的情况。响应者中沙眼衣原体感染的患病率为2.02%,报告的衣原体感染病史为36%(34/95)。在响应者中,92%(229/249)在不同程度上担心感染性传播感染;然而,大多数(72%;174/242)认为风险较低。

结论

使用基于网络的答案管理进行家庭筛查是一种可行的性传播感染筛查工具,它降低了高危人群的参与门槛。然而,在这个特定人群中,响应率过低,无法常规采用。

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