Choi A, Sarang A
Broomfield Hospital, Chelmsford CM1 7ET, UK.
Anaesthesia. 2007 Jul;62(7):737-40. doi: 10.1111/j.1365-2044.2007.05000.x.
Dapsone can alter the oxygen carrying capacity of haemoglobin. Some patients are more susceptible to these effects because of genetic factors, comorbidities or peri-operative factors such as anaemia. We present a 57-year-old lady who underwent elective coronary artery bypass grafting. Deterioration in neurological and respiratory condition prompted a review of her drug treatment. A combination of long-term dapsone therapy, co-existing cardiac and respiratory disease, postoperative anaemia and renal impairment contributed to her decompensation, despite a relatively low level of methaemoglobin. Successful management included stopping dapsone therapy, supportive care and administration of ascorbic acid.
氨苯砜可改变血红蛋白的携氧能力。由于遗传因素、合并症或围手术期因素（如贫血），一些患者对这些影响更为敏感。我们报告一位57岁接受择期冠状动脉搭桥术的女性患者。神经和呼吸状况的恶化促使对其药物治疗进行评估。尽管高铁血红蛋白水平相对较低，但长期氨苯砜治疗、并存的心脏和呼吸系统疾病、术后贫血及肾功能损害共同导致了她的失代偿。成功的治疗措施包括停用氨苯砜治疗、支持治疗及给予维生素C。
