Siniluoto T, Päivänsalo M, Alavaikko M
Department of Diagnostic Radiology, University Central Hospital, University of Oulu, Finland.
Eur J Radiol. 1991 Nov-Dec;13(3):181-6. doi: 10.1016/0720-048x(91)90025-q.
Ultrasound (US) findings and accuracy in detecting splenic and hepatic involvement were analysed in 137 unselected, untreated patients with Hodgkin's disease. Histology was available from the spleens of 61 patients and the livers of 59 patients. In 20 patients the spleen appeared abnormal at US; containing focal hypoechoic lesions in 14, being enlarged in 13 and inhomogeneous in 2 patients. Most focal lesions were less than 10 mm. The sensitivity of US in detecting involvement of the spleen was 54% and the specificity 100%; the ability of US to detect hypoechoic splenic lesions improved during the study period. Focal hypoechoic hepatic lesions were found in three patients; histological examination of these showed benign changes in one and suspicious finding in the second. In the third the lesion disappeared during chemotherapy. In three cases with definitive histological evidence of liver involvement, US results were false-negative. The results indicate a higher diagnostic efficacy for US in the detection of splenic than hepatic involvement by Hodgkin's disease.
对137例未经挑选、未接受治疗的霍奇金病患者的超声（US）检查结果以及检测脾脏和肝脏受累情况的准确性进行了分析。61例患者的脾脏和59例患者的肝脏有组织学检查结果。20例患者的脾脏在超声检查中显示异常；14例有局灶性低回声病变，13例脾脏肿大，2例回声不均匀。大多数局灶性病变小于10毫米。超声检测脾脏受累的敏感性为54%，特异性为100%；在研究期间，超声检测低回声脾脏病变的能力有所提高。3例患者发现局灶性肝脏低回声病变；其中1例组织学检查显示为良性改变，第2例有可疑发现。第3例患者的病变在化疗期间消失。在3例有明确肝脏受累组织学证据的病例中，超声检查结果为假阴性。结果表明，超声在检测霍奇金病脾脏受累方面的诊断效能高于肝脏受累。
