Izquierdo G, Campoy F, Mir J, Gonzalez M, Martinez-Parra C
Department of Neurology, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Eur J Radiol. 1991 Nov-Dec;13(3):220-4. doi: 10.1016/0720-048x(91)90034-s.
Thirty-five patients with definite multiple sclerosis (MS) were studied. They underwent neuropsychological testing and magnetic resonance imaging (MRI). The MRI findings at different brain areas levels were compared with the neuropsychological findings. A quantitative system was used to measure MRI-MS lesions. In this series, a positive correlation was established between memory and learning disturbances measured by Battery 144, and the lesions measured by MRI (total, hemispheric and, particularly, periventricular lesions). MRI can detect MS lesions, and this study shows that a correlation between MRI and neuropsychological findings is possible if quantitative methods are used to distinguish different MS involvement areas in relation to neuropsychological tasks. These findings suggest that hemispheric lesions in MS produce cognitive disturbances and MRI could be a useful tool in predicting memory and learning impairment.
对35例确诊为多发性硬化症（MS）的患者进行了研究。他们接受了神经心理学测试和磁共振成像（MRI）检查。将不同脑区水平的MRI检查结果与神经心理学检查结果进行了比较。采用定量系统来测量MRI检测到的MS病灶。在本研究系列中，通过144项成套测验测得的记忆和学习障碍与MRI测得的病灶（总计、半球及尤其是脑室周围病灶）之间建立了正相关关系。MRI能够检测出MS病灶，并且本研究表明，如果采用定量方法来区分与神经心理学任务相关的不同MS受累区域，那么MRI与神经心理学检查结果之间可能存在相关性。这些发现提示，MS中的半球病灶会导致认知障碍，并且MRI可能是预测记忆和学习障碍的有用工具。
