Anzola G P, Bevilacqua L, Cappa S F, Capra R, Faglia L, Farina E, Frisoni G, Mariani C, Pasolini M P, Vignolo L A
Clinica Neurologica dell'Università di Brescia, Italy.
J Neurol Neurosurg Psychiatry. 1990 Feb;53(2):142-5. doi: 10.1136/jnnp.53.2.142.
Forty one moderately impaired patients with clinically confirmed multiple sclerosis (MS) and a relapsing-remitting course were submitted to a neuropsychological battery and magnetic resonance imaging (MRI) to correlate the neuropsychological performances with the degree of cerebral demyelination. The neuropsychological results were indicative of a very mild overall impairment. The patients were subdivided into two groups (extensive periventricular demyelination or discrete lesions on MRI) and the results of neuropsychological tests compared. Patients with extensive periventricular demyelination had an inferior performance on concept formation, non-verbal reasoning and verbal memory tests.
41例临床确诊为复发缓解型多发性硬化（MS）且中度受损的患者接受了神经心理成套测验和磁共振成像（MRI）检查，以将神经心理表现与脑脱髓鞘程度相关联。神经心理学结果显示整体损伤非常轻微。患者被分为两组（MRI显示脑室周围广泛脱髓鞘或散在病灶），并比较神经心理测试结果。脑室周围广泛脱髓鞘的患者在概念形成、非语言推理和语言记忆测试中的表现较差。
