parE基因新突变对产超广谱β-内酰胺酶大肠埃希菌分离株喹诺酮耐药性的影响
Contribution of a new mutation in parE to quinolone resistance in extended-spectrum-beta-lactamase-producing Escherichia coli isolates.
作者信息
Sorlozano Antonio, Gutierrez Jose, Jimenez Antonio, de Dios Luna Juan, Martínez José Luis
机构信息
Departments of Microbiology, University of Granada, Granada, Spain.
出版信息
J Clin Microbiol. 2007 Aug;45(8):2740-2. doi: 10.1128/JCM.01093-07. Epub 2007 Jun 13.
Abstract
Mutations in the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE were studied in 30 fluoroquinolone-resistant clinical isolates of Escherichia coli producing extended-spectrum beta-lactamases. Ten isolates showed a mutation in parE that was significantly associated with an increase in the MIC for fluoroquinolones.
摘要
在30株产超广谱β-内酰胺酶的耐氟喹诺酮类大肠杆菌临床分离株中，研究了gyrA、gyrB、parC和parE喹诺酮耐药决定区的突变情况。10株分离株显示parE发生突变，这与氟喹诺酮类药物的最低抑菌浓度升高显著相关。
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