Waters Michael, Yauk Carole
Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA. mdwaters@bellsouth
Environ Mol Mutagen. 2007 Jun;48(5):400-3. doi: 10.1002/em.20289.
The number of high throughput -omics technologies continues to grow. Toxicogenomic application of these technologies is poised to greatly influence current regulatory toxicology. However, many changes are needed before a systems biology level approach can be effectively incorporated into the regulatory toxicology framework. A workshop was held at the Annual Environmental Mutagen Society meeting in Vancouver, British Columbia, on advances in -omics applications. A number of recommendations emerged from the workshop discussion (beyond what activities are currently ongoing) aimed at advancing the ultimate goal of predictive systems toxicology from the present formative state of toxicogenomics. Recommendations include: (1) encouraging investigators to embrace open-access data sharing, (2) increasing current database and curation capacity, (3) establishment of large collaborative projects investigating multiple -omics endpoints within the same groups of animals, (4) mechanisms to encourage collaborative science including increasing the value of junior authorship on multi-authored papers and changes in the promotion process, (5) further development of standardized protocols, and (6) investment from the funding agencies and toxicology community to build the required infrastructure.
高通量组学技术的数量持续增长。这些技术在毒理基因组学方面的应用有望极大地影响当前的监管毒理学。然而，在将系统生物学层面的方法有效纳入监管毒理学框架之前，还需要进行许多变革。在不列颠哥伦比亚省温哥华举行的年度环境诱变剂学会会议上举办了一次关于组学应用进展的研讨会。研讨会讨论产生了一些建议（超出了目前正在进行的活动），旨在从当前毒理基因组学的形成状态推进预测性系统毒理学的最终目标。建议包括：（1）鼓励研究人员接受开放获取的数据共享；（2）提高当前数据库和管理能力；（3）建立大型合作项目，在同一组动物中研究多个组学终点；（4）鼓励合作科研的机制，包括提高多作者论文中初级作者的价值以及改变晋升过程；（5）进一步制定标准化方案；（6）资助机构和毒理学界进行投资，以建立所需的基础设施。
