Lanctôt Krista L, Hussey Doug F, Herrmann Nathan, Black Sandra E, Rusjan Pablo M, Wilson Alan A, Houle Sylvain, Kozloff Nicole, Verhoeff Nicholaas Paul L G, Kapur Shitij
Neuropharmacology Research Program and Geriatric Psychiatry, Toronto, Ontario, Canada.
Am J Geriatr Psychiatry. 2007 Oct;15(10):888-98. doi: 10.1097/JGP.0b013e3180488325. Epub 2007 Jun 13.
The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT(1A)]) receptors in cognition, behavior, and drug response is increasingly being recognized. Postmortem studies suggest decreased 5-HT(1A) receptors in patients with Alzheimer disease (AD), but this has not been confirmed in vivo. Our primary objective was to assess the extent of 5-HT(1A) receptor losses in mild to moderate AD.
The authors examined 5-HT(1A) receptors in 10 patients with mild to moderate AD and 10 healthy volunteers with the same sex and similar age using positron emission tomography imaging with the selective 5-HT(1A) receptor radioligand, [(11)C]WAY-100635. Regions of interest (ROIs) were manually drawn on coregistered magnetic resonance images for the frontal, lateral temporal, medial temporal (MTC), parietal, and cerebellar cortices. Using the simplified reference tissue model, 5-HT(1A) binding potentials (BPs) were calculated relative to the cerebellum.
After adjusting for partial volume effects, ROI analysis showed a significant group effect (AD versus comparison group) on BP. Analysis of between-subjects factors showed significantly decreased 5-HT(1A) BP in the right MTC, but not in the other ROIs.
Given the strategic role of these receptors, loss of right medial temporal 5-HT(1A) receptors might play an important role in AD symptomatology.
血清素-1A（5-羟色胺-1A [5-HT(1A)]）受体在认知、行为及药物反应中的重要作用日益受到认可。尸检研究表明，阿尔茨海默病（AD）患者的5-HT(1A)受体减少，但这尚未在活体中得到证实。我们的主要目的是评估轻至中度AD患者中5-HT(1A)受体丧失的程度。
作者使用选择性5-HT(1A)受体放射性配体[(11)C]WAY-100635，通过正电子发射断层扫描成像，对10例轻至中度AD患者和10名年龄、性别匹配的健康志愿者的5-HT(1A)受体进行了检测。在配准后的磁共振图像上，手动绘制额叶、颞叶外侧、颞叶内侧（MTC）、顶叶和小脑皮质的感兴趣区域（ROI）。使用简化参考组织模型，相对于小脑计算5-HT(1A)结合电位（BP）。
校正部分容积效应后，ROI分析显示BP存在显著的组间效应（AD组与对照组）。受试者间因素分析显示，右侧MTC的5-HT(1A) BP显著降低，但其他ROI未见此现象。
鉴于这些受体的关键作用，右侧颞叶内侧5-HT(1A)受体的丧失可能在AD症状学中起重要作用。
