对肾单位近远轴上节段化的分子见解。
Molecular insights into segmentation along the proximal-distal axis of the nephron.
作者信息
Kopan Raphael, Cheng Hui-Teng, Surendran Kameswaran
机构信息
Department of Molecular Biology, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
J Am Soc Nephrol. 2007 Jul;18(7):2014-20. doi: 10.1681/ASN.2007040453. Epub 2007 Jun 13.
Abstract
The structure of a mammalian kidney is parsed into large collections of polarized nephrons, and each segment is home to a diverse community of cells that specialize in renal endocrine and excretory functions. Early developmental lengthening and diversification of nephron segments along a proximal--distal axis initiate all subsequent facets of tubular growth and function. Morphogenic cues and biochemical interactions that are critical to this process are starting to emerge. The underlying principles of regional cell signaling and transcriptional control organizing early segmentation are the subject of this review.
摘要
哺乳动物肾脏的结构被解析为大量极化的肾单位集合，每个节段都有各种各样的细胞群落，这些细胞专门负责肾脏的内分泌和排泄功能。肾单位节段沿近 - 远轴的早期发育延长和多样化启动了肾小管生长和功能的所有后续方面。对这一过程至关重要的形态发生线索和生化相互作用开始显现。组织早期节段化的区域细胞信号传导和转录控制的基本原理是本综述的主题。
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