Nasr Samih H, D'Agati Vivette D
Department of Pathology, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA.
J Am Soc Nephrol. 2007 Jul;18(7):2032-6. doi: 10.1681/ASN.2006121328. Epub 2007 Jun 13.
Emerging evidence supports that the entity known as idiopathic nodular glomerulosclerosis is not idiopathic. A strong causative association with longstanding cigarette smoking and hypertension has been identified. Morphologically, smoking-associated nodular glomerulosclerosis closely resembles diabetic nephropathy. The potential roles of advanced glycation end products, oxidative stress, angiogenesis, and hemodynamic perturbations are explored.
新出现的证据支持，所谓的特发性结节性肾小球硬化并非特发性。已确定其与长期吸烟和高血压存在强烈的因果关联。在形态学上，吸烟相关的结节性肾小球硬化与糖尿病肾病极为相似。文中探讨了晚期糖基化终末产物、氧化应激、血管生成和血流动力学紊乱的潜在作用。
