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糖耐量受损的肾移植受者的结节性肾小球硬化症:糖尿病还是特发性?病例报告及文献复习。

Nodular glomerulosclerosis in a kidney transplant recipient with impaired glucose tolerance: diabetic or idiopathic? A case report and literature review.

机构信息

Department of Renal Medicine, Singapore General Hospital, Outram Rd, Singapore, 169608, Singapore.

Division of Pathology, Singapore General Hospital, Singapore, Singapore.

出版信息

CEN Case Rep. 2021 May;10(2):273-280. doi: 10.1007/s13730-020-00546-x. Epub 2021 Jan 3.

DOI:10.1007/s13730-020-00546-x
PMID:33393072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8019450/
Abstract

Nodular glomerulosclerosis, typically diagnosed in patients with diabetes mellitus, has been reported in native kidneys of pre-diabetic patients but similar cases in kidney transplant recipients are lacking. We describe a case of nodular glomerulosclerosis in a kidney transplant recipient who had not been found to be diabetic despite regular screening and discuss the implications for the pathogenesis and diagnosis of nodular glomerulosclerosis and screening of post-transplant diabetes mellitus.

摘要

结节性肾小球硬化症,通常在糖尿病患者中诊断,已在非糖尿病患者的原肾中报告,但在肾移植受者中缺乏类似病例。我们描述了一例肾移植受者的结节性肾小球硬化症病例,尽管进行了常规筛查,但未发现该患者患有糖尿病,并讨论了结节性肾小球硬化症发病机制和诊断以及移植后糖尿病筛查的意义。

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本文引用的文献

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Glycemic Monitoring and Management in Advanced Chronic Kidney Disease.血糖监测与管理在慢性肾脏病晚期中的应用。
Endocr Rev. 2020 Oct 1;41(5):756-74. doi: 10.1210/endrev/bnaa017.
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Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets.糖尿病肾病的病理生理机制:关注当前和未来的治疗靶点。
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Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study.尽管进行了强化血糖控制,移植肾后仍会发生糖尿病肾病:一项观察性队列研究。
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Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity?肾脏疾病中的胰岛素抵抗:是否存在与糖尿病或肥胖不同的独特作用?
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AGEs-RAGE overexpression in a patient with smoking-related idiopathic nodular glomerulosclerosis.吸烟相关特发性结节性肾小球硬化症患者中晚期糖基化终末产物受体(AGEs-RAGE)的过表达
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Performance of non-traditional hyperglycemia biomarkers by chronic kidney disease status in older adults with diabetes: Results from the Atherosclerosis Risk in Communities Study.非传统高血糖生物标志物在老年糖尿病患者慢性肾脏病中的表现:社区动脉粥样硬化风险研究的结果。
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A case of "hidden" diabetic nephropathy diagnosed by a combination of renal biopsy findings and continuous glucose monitoring system.一例通过肾活检结果与连续血糖监测系统相结合诊断出的“隐匿性”糖尿病肾病病例。
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