Brousseau Maud, Bertrand Gérard, Lavoine Eric, Kettani Sami, Rabarin Fabrice, Saint-Cast Yann, Massin Philippe, Rousselet Marie-Christine
Service d'Anatomie Pathologique, Centre Hospitalier Universitaire, 4, rue Larrey, 49993 Angers Cedex 9.
Ann Pathol. 2007 Feb;27(1):38-42. doi: 10.1016/s0242-6498(07)88684-6.
Acral myxoinflammatory fibroblastic sarcoma is a rare low-grade malignant soft tissue tumor, usually observed in the extremities of middle-aged adults. We report two cases which occurred in the thumb and knee of middle-aged women. Both tumors showed a multinodular architecture, with cellular areas, occasional foci of hyalinized fibrosis, and hypocellular areas with a myxoid background. Various neoplastic cells were identified including spindled or rounded epithelioid cells and occasional bizarre giant cells, morphologically mimicking Reed-Sternberg cells or ganglion cells. Tumor cells were strongly immunoreactive for vimentin, and variably positive for CD68 and CD34. Both tumors were completely resected and patients were free of disease without any further treatment after a mean follow-up of 14 months.
肢端黏液炎性纤维母细胞肉瘤是一种罕见的低级别恶性软组织肿瘤，通常见于中年成年人的四肢。我们报告两例发生在中年女性拇指和膝部的病例。两个肿瘤均呈多结节结构，有细胞区域、偶尔的玻璃样变纤维化灶以及伴有黏液样背景的细胞稀少区域。鉴定出了各种肿瘤细胞，包括梭形或圆形上皮样细胞以及偶尔的怪异巨细胞，形态上类似里德-斯腾伯格细胞或神经节细胞。肿瘤细胞对波形蛋白呈强免疫反应性，对CD68和CD34呈不同程度阳性。两个肿瘤均被完整切除，平均随访14个月后，患者未经任何进一步治疗，无疾病复发。
