Srivastava Pallavi, Husain Nuzhat, Neyaz Azfar, Gupta Vani
Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
BMJ Case Rep. 2018 Jul 18;2018:bcr-2018-224259. doi: 10.1136/bcr-2018-224259.
Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue sarcoma which was initially observed in acral sites and characterised by spindle cells, pleomorphic bizarre cells and distinctive large Reed-Sternberg-like cells admixed with an intense inflammatory cell infiltrates. MIFS manifests as a slow growing often superficial lesion which can be mistaken as infectious or chronic inflammatory process or benign tumours such as nodular fasciitis, giant cell tumour of tendon sheath or synovial pseudocyst. We report a rare presentation of a MIFS in a 38-year-old man with extensive local spread from subcutaneous tissue to the ankle joint and bones as well as multiple synchronous metastases to lung, sixth rib and vertebra. Our case is peculiar for its aggressive clinical behaviour with short duration, fast growth and extensive metastases, a feature infrequent in MIFS.
黏液样炎性纤维母细胞肉瘤（MIFS）是一种罕见的软组织肉瘤，最初在肢端部位被观察到，其特征为梭形细胞、多形性奇异细胞以及与密集炎性细胞浸润混合的独特的大里德-斯特恩伯格样细胞。MIFS表现为生长缓慢且通常位于浅表的病变，可被误诊为感染性或慢性炎症过程，或误诊为良性肿瘤，如结节性筋膜炎、腱鞘巨细胞瘤或滑膜假囊肿。我们报告了一例罕见的MIFS病例，患者为一名38岁男性，病变从皮下组织广泛局部扩散至踝关节和骨骼，同时伴有肺、第六肋骨和椎骨的多发同步转移。我们的病例因其侵袭性的临床行为而独特，病程短、生长快且转移广泛，这一特征在MIFS中并不常见。
