Brito Carlos A A, Albuquerque Maria de Fátima M P, Lucena-Silva Norma
Centro de Pesquisas Aggeu Magalhães, Fundação Instituto Osvaldo Cruz, Recife, PE.
Rev Soc Bras Med Trop. 2007 Mar-Apr;40(2):220-3. doi: 10.1590/s0037-86822007000200015.
Evidence of vascular leakage due to increased capillary permeability characterizes and differentiates dengue hemorrhagic fever. This article assesses the value of serum albumin for detecting vascular permeability abnormalities in dengue cases. Fourteen patients diagnosed with dengue hemorrhagic fever at two private hospitals in Recife, Brazil, between January and May 2002 were followed up with daily hematocrit and serum albumin assays. Ultrasound scans and chest X-rays were also performed. Eight (57%) of the cases presented hemoconcentration of 20% or more. Hypoalbuminemia was detected in ten patients (71%). Serum albumin assays increased the detection of permeability abnormalities in six cases (43%) in which the hemoconcentration was less than 20% and the symptoms were compatible with an exacerbated immune response. The X-rays were normal in all cases. Thus, the use serum albumin quantification increased the sensitivity of dengue hemorrhagic fever detection.
由于毛细血管通透性增加导致的血管渗漏证据是登革出血热的特征并使其得以鉴别。本文评估血清白蛋白在检测登革热病例血管通透性异常方面的价值。2002年1月至5月间，对巴西累西腓两家私立医院诊断为登革出血热的14名患者进行每日血细胞比容和血清白蛋白检测随访。还进行了超声扫描和胸部X光检查。8例（57%）病例出现20%或更高的血液浓缩。10名患者（71%）检测到低白蛋白血症。血清白蛋白检测增加了6例（43%）通透性异常的检测，这些病例血液浓缩小于20%且症状与免疫反应加剧相符。所有病例的X光检查均正常。因此，血清白蛋白定量检测提高了登革出血热检测的敏感性。
