Chen Ai-Zheng, Pu Xi-Ming, Kang Yun-Qing, Liao Li, Yao Ya-Dong, Yin Guang-Fu
College of Materials Science and Engineering, Sichuan University, Chengdu, 610064 Sichuan, China.
J Mater Sci Mater Med. 2007 Dec;18(12):2339-45. doi: 10.1007/s10856-007-3173-8. Epub 2007 Jun 14.
Poly(L-lactide) (PLLA) microparticles were prepared in supercritical anti-solvent process. The effects of several key factors on surface morphology, and particle size and particle size distribution were investigated. These factors included initial drops size, saturation ratio of PLLA solution, pressure, temperature, concentration of the organic solution, the flow rate of the solution and molecular weight of PLLA. The results indicated that the saturation ratio of PLLA solution, concentration of the organic solution and flow rate of the solution played important roles on the properties of products. Various microparticles with the mean particle size ranging from 0.64 to 6.64 microm, could be prepared by adjusting the operational parameters. Fine microparticles were obtained in a process namely solution-enhanced dispersion by supercritical fluids (SEDS) process with dichloromethane/acetone mixture as solution.
聚左旋乳酸（PLLA）微粒通过超临界抗溶剂过程制备。研究了几个关键因素对表面形态、粒径和粒径分布的影响。这些因素包括初始液滴大小、PLLA溶液的饱和度、压力、温度、有机溶液浓度、溶液流速以及PLLA的分子量。结果表明，PLLA溶液的饱和度、有机溶液浓度和溶液流速对产物性能起着重要作用。通过调整操作参数，可以制备出平均粒径在0.64至6.64微米范围内的各种微粒。以二氯甲烷/丙酮混合物为溶液，通过超临界流体增强溶液分散（SEDS）过程可获得精细的微粒。
