Acs Nándor, Bánhidy Ferenc, Puhó Erzsébet H, Czeizel Andrew E
Second Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary.
Eur J Epidemiol. 2007;22(8):557-64. doi: 10.1007/s10654-007-9143-0. Epub 2007 Jun 14.
The objective of the study was to estimate association between maternal glomerulonephritis during pregnancy and structural birth defects, i.e. congenital abnormalities. The prevalence of maternal glomerulonephritis during the first trimester of pregnancy in cases with different congenital abnormalities was compared to that of matched controls without congenital abnormalities in the population-based Hungarian Case-Control Surveillance System of Congenital Abnormalities. Of 22,843 cases with congenital abnormalities, 309 (1.35%) had mothers with glomerulonephritis during pregnancy, compared to 479 (1.26%) of 38,151 controls (adjusted POR with 95% CI = 1.0, 0.9-1.2). Specified groups of congenital abnormalities were also assessed versus controls. Cases with isolated intestinal atresia/stenosis (adjusted POR with 95% CI: 6.8, 1.3-37.4) based on five cases were more likely to have mothers with prospectively and medically recorded glomerulonephritis. In conclusion a higher rate of congenital isolated intestinal atresia/stenosis may be associated with the maternal glomerulonephritis. However, this finding is considered only as signal and further studies are needed to confirm or reject this possible association.
该研究的目的是评估孕期母亲患肾小球肾炎与结构性出生缺陷（即先天性异常）之间的关联。在匈牙利基于人群的先天性异常病例对照监测系统中，将不同先天性异常病例在妊娠头三个月期间母亲患肾小球肾炎的患病率与无先天性异常的匹配对照的患病率进行了比较。在22,843例先天性异常病例中，309例（1.35%）的母亲在孕期患有肾小球肾炎，相比之下，38,151例对照中有479例（1.26%）（调整后的比值比及95%置信区间=1.0，0.9 - 1.2）。还对特定组的先天性异常与对照进行了评估。基于五例病例，孤立性肠道闭锁/狭窄病例（调整后的比值比及95%置信区间：6.8，1.3 - 37.4）的母亲更有可能有前瞻性医学记录的肾小球肾炎。总之，先天性孤立性肠道闭锁/狭窄的较高发生率可能与母亲患肾小球肾炎有关。然而，这一发现仅被视为一个信号，需要进一步研究来证实或否定这种可能的关联。
