Turgut Sebahat, Ergin Seniz, Turgut Günfer, Erdoğan Berna Sanli, Aktan Sebnem
Department of Physiology Faculty of Medicine, Pamukkale University, Denizli, Turkey.
J Basic Clin Physiol Pharmacol. 2007;18(1):11-9. doi: 10.1515/jbcpp.2007.18.1.11.
Mal de Meleda (MDM) is a rare autosomal recessively inherited palmoplantar keratoderma. In 1826 Stulli described the disease on the Dalmatian island of Meleda. Hyperkeratosis involves other parts of the body such as elbows and knees, in addition to the palms and soles. Zinc deficiency is known to cause hyperkeratozis in addition to other skin changes. We studied the levels of essential and nonessential elements in blood and tissues /nail, hair, skin/ in MDM patients and healthy controls living in Köprüçay area, Turkey. The results show no significant difference in blood zinc, iron, copper, cadmium, and lead levels between MDM patients and healthy controls. The zinc and copper levels of nail and hair in MDM patients did not differ from those of healthy controls.
梅勒达病（MDM）是一种罕见的常染色体隐性遗传性掌跖角化病。1826年，斯图利在达尔马提亚的梅勒达岛上描述了这种疾病。除了手掌和脚底，角化过度还累及身体的其他部位，如肘部和膝盖。众所周知，锌缺乏除了会导致其他皮肤变化外，还会引起角化过度。我们研究了生活在土耳其科普吕恰伊地区的MDM患者和健康对照者血液和组织/指甲、头发、皮肤中必需和非必需元素的水平。结果显示，MDM患者与健康对照者的血液锌、铁、铜、镉和铅水平无显著差异。MDM患者指甲和头发中的锌和铜水平与健康对照者无异。
