Zhang Qian, Wu Zong-shan, Zhang Dan
Department of Urology, Fuxing Hospital Affiliated to Capital University of Medical Science, Beijing 100038, China.
Zhonghua Nan Ke Xue. 2007 May;13(5):417-20.
To investigate the clinical significance and diagnosis of testicular microlithiasis (TM).
We reported 2 cases of TM, reviewed the relevant published literature and analyzed the clinical significance of the condition.
Ultrasonographic (US) scanning of the scrotal revealed multiple small calcifications diffusely scattered throughout the testicular parenchyma with rare pinpoint-like 1-2 mm shadows but without acoustic ones, which were diagnosed by scrotal sonography as right limited TM and classic TM accompanied with left varicocele and epididymitis. The testicular tumor markers of AFP, hCG, LDH and testosterone were shown to be normal, so that no intervention was performed for TM. During the 6-8 months follow-up, no abnormality was found in physical examinations and testicular tumor markers, and no characteristic additive change was revealed by testicular ultrasound.
TM is a rare, usually asymptomatic and non-progressive abnormality, usually detected incidentally during the ultrasound examination of the testis. Though it is still controversial whether TM should be regarded as a premalignant lesion or not, regular follow-up and routine ultrasound examination are quite necessary for TM patients.
探讨睾丸微石症（TM）的临床意义及诊断方法。
报告2例TM病例，回顾相关已发表文献并分析该病症的临床意义。
阴囊超声扫描显示，睾丸实质内弥漫性散在多个小钙化灶，有罕见的1 - 2毫米点状阴影，但无声影，经阴囊超声诊断为右侧局限性TM以及伴有左侧精索静脉曲张和附睾炎的典型TM。甲胎蛋白（AFP）、人绒毛膜促性腺激素（hCG）、乳酸脱氢酶（LDH）和睾酮等睾丸肿瘤标志物显示正常，因此未对TM进行干预。在6 - 8个月的随访期间，体格检查和睾丸肿瘤标志物均未发现异常，睾丸超声也未显示特征性的附加变化。
TM是一种罕见的、通常无症状且无进展的异常情况，通常在睾丸超声检查时偶然发现。尽管TM是否应被视为癌前病变仍存在争议，但对TM患者进行定期随访和常规超声检查是非常必要的。
