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睾丸微石症——一种可能的癌前病变。五例报告及文献复习。

Testicular microlithiasis--a possibly premalignant condition. Report of five cases and a review of the literature.

作者信息

Berger A, Brabrand K

机构信息

Department of Radiology, Ullevål Hospital, Oslo, Norway.

出版信息

Acta Radiol. 1998 Sep;39(5):583-6. doi: 10.1080/02841859809172231.

DOI:10.1080/02841859809172231
PMID:9755714
Abstract

Testicular microlithiasis (TM) is a rare condition characterized by the presence of multiple small intratesticular calcifications. The etiology is unknown but the condition has been observed in a variety of different urological conditions. We report on 5 cases diagnosed by ultrasonography at our departments from 1992 to 1994. A review of the literature plus our present 5 cases gives a total of 124 reported cases of TM. TM was associated with testicular malignancy in 44 patients (35%) of whom 24 (19%) had a seminoma and 20 (16%) a non-seminoma. There were 4 reports of testicular malignancy developing in patients with a prior diagnosis of TM. The condition should be considered premalignant and a careful follow-up of TM patients is advocated.

摘要

睾丸微石症(TM)是一种罕见病症,其特征为睾丸内存在多个小钙化灶。病因不明,但在多种不同的泌尿系统疾病中均观察到了这种情况。我们报告了1992年至1994年在我们科室通过超声诊断的5例病例。文献回顾加上我们目前的5例病例,共有124例报道的睾丸微石症病例。44例(35%)睾丸微石症患者与睾丸恶性肿瘤相关,其中24例(19%)患有精原细胞瘤,20例(16%)患有非精原细胞瘤。有4例报告显示,先前诊断为睾丸微石症的患者发生了睾丸恶性肿瘤。应将这种情况视为癌前病变,主张对睾丸微石症患者进行密切随访。

相似文献

1
Testicular microlithiasis--a possibly premalignant condition. Report of five cases and a review of the literature.睾丸微石症——一种可能的癌前病变。五例报告及文献复习。
Acta Radiol. 1998 Sep;39(5):583-6. doi: 10.1080/02841859809172231.
2
Unilateral testicular microlithiasis associated with a seminoma.单侧睾丸微石症伴精原细胞瘤。
J Clin Ultrasound. 1997 Nov-Dec;25(9):505-7. doi: 10.1002/(sici)1097-0096(199711/12)25:9<505::aid-jcu8>3.0.co;2-r.
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Testicular microlithiasis associated with seminoma: Gray-scale and color Doppler ultrasound findings.睾丸微结石症合并精原细胞瘤:灰阶及彩色多普勒超声表现
Urol Int. 1996;57(4):255-8. doi: 10.1159/000282928.
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Case of mediastinal seminoma with testicular microlithiasis.纵隔精原细胞瘤合并睾丸微结石症病例
Int J Urol. 2002 Feb;9(2):114-6. doi: 10.1046/j.1442-2042.2002.00431.x.
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[The association of microlithiasis and malignant testicular neoplasms. The echographic pictures in one patient].[微结石症与睾丸恶性肿瘤的关联。一名患者的超声图像]
Radiol Med. 1994 Nov;88(5):699-701.
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The interval of development of testicular carcinoma in a patient with previously demonstrated testicular microlithiasis.一名先前已证实患有睾丸微结石症患者的睾丸癌发展间隔时间。
J Urol. 2000 Jan;163(1):239.
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Testicular microlithiasis: a benign condition with a malignant association.睾丸微结石症:一种伴有恶性关联的良性病症。
J Clin Ultrasound. 1996 May;24(4):197-202. doi: 10.1002/(SICI)1097-0096(199605)24:4<197::AID-JCU6>3.0.CO;2-A.
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[The significance of testicular microlithiasis].[睾丸微石症的意义]
Ugeskr Laeger. 2014;176(34).
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[Testicular microlithiasis: a report of 2 cases and review of the literature].[睾丸微结石症:2例报告并文献复习]
Zhonghua Nan Ke Xue. 2007 May;13(5):417-20.
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Diffuse testicular microlithiasis associated with intratubular germ cell neoplasia and seminoma.弥漫性睾丸微结石症伴管内生殖细胞肿瘤和精原细胞瘤。
Urology. 1996 Nov;48(5):794-6. doi: 10.1016/s0090-4295(96)00228-2.

引用本文的文献

1
Testicular microlithiasis: is there a need for surveillance in the absence of other risk factors?睾丸微石症:在没有其他危险因素的情况下是否需要进行监测?
Eur Radiol. 2012 Nov;22(11):2540-6. doi: 10.1007/s00330-012-2520-4. Epub 2012 Jun 19.
2
Testicular microlithiasis heralding mixed germ cell tumor of the testis in a boy.睾丸微结石症预示着一名男孩患睾丸混合性生殖细胞肿瘤。
J Endocrinol Invest. 2006 Jan;29(1):82-5. doi: 10.1007/BF03349182.
3
Surveillance of testicular microlithiasis? Results of an UK based national questionnaire survey.
睾丸微结石症的监测?一项基于英国的全国问卷调查结果。
BMC Urol. 2006 Mar 15;6:8. doi: 10.1186/1471-2490-6-8.
4
Bilateral germ-cell tumours: 22-year experience at the Institut Gustave Roussy.双侧生殖细胞肿瘤:古斯塔夫·鲁西研究所22年的经验
Br J Cancer. 2004 Jan 12;90(1):55-9. doi: 10.1038/sj.bjc.6601464.
5
Testicular microlithiasis: clinical significance and review of the literature.睾丸微石症:临床意义及文献综述
Eur Radiol. 2003 Dec;13(12):2567-76. doi: 10.1007/s00330-003-2014-5. Epub 2003 Oct 3.
6
Effects of testicular microlithiasis on Doppler parameters: report of three cases.睾丸微石症对多普勒参数的影响:三例报告
BMC Urol. 2002;2:3. doi: 10.1186/1471-2490-2-3. Epub 2002 Feb 13.