Lo T C, Wiley A L, Ansfield F J, Brandenburg J H, Davis H L, Gollin F F, Johnson R O, Ramirez G, Vermund H
AJR Am J Roentgenol. 1976 Feb;126(2):229-35. doi: 10.2214/ajr.126.2.229.
In 1961, a randomized study was begun at the University of Wisconsin Medical Center in which the treatment of advanced squamous cell carcinoma of the head and neck with radiation therapy was compared with combined treatment with radiation therapy and 5-Fluorouracil. One hundred and thirty-six patients with primary lesions in the oral cavity, the base of the tongue, and the oropharynx were analyzed. Both local control and survival were better in the combined treatment group than in the group with radiation therapy alone. However, in only the oral cavity patient population was the difference statistically significant. Both acute and late complications were also increased in this group of patients who received combined treatment.
1961年，威斯康星大学医学中心开展了一项随机研究，比较了头颈部晚期鳞状细胞癌单纯放射治疗与放射治疗联合5-氟尿嘧啶治疗的效果。分析了136例口腔、舌根和口咽原发性病变患者。联合治疗组的局部控制和生存率均优于单纯放射治疗组。然而，仅在口腔患者群体中，差异具有统计学意义。接受联合治疗的这组患者的急性和晚期并发症也有所增加。
