新辅助、同步和辅助化疗治疗头颈部鳞状细胞癌的疗效评估：一项荟萃分析。
Evaluation of neo-adjuvant, concurrent and adjuvant chemotherapy in the treatment of head and neck squamous cell carcinoma: a meta-analysis.
作者信息
Akhlaghi Fahimeh, Esmaeelinejad Mohammad, Shams Amin, Augend Arsalan
机构信息
Associate Professor,, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Resident, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
J Dent (Tehran). 2014 May;11(3):290-301. Epub 2014 May 31.
OBJECTIVE
Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity. This study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.
MATERIALS AND METHODS
The authors searched all electronic databases (Medline, Embase and Cochrane) for all the articles published from 1970 to January 2011. Data of the evaluated treatment procedures (chemotherapy or radiotherapy), number of patients, publishing date and the authors' names have all been extracted from the articles and have been categorized in a table.
RESULTS
Forty-six researches are included in this study. All three ways show that using chemotherapy after or with radiotherapy improves the vitality rate significantly (p-value< 0.01).
CONCLUSION
It is concluded that after deciding not to perform a surgery for treating SCC, the recommended treatment plan is chemotherapy and radiotherapy simultaneously.
目的
鳞状细胞癌（SCC）是口腔最常见的恶性肿瘤。本研究旨在通过荟萃分析评估包括新辅助治疗、同步放化疗和辅助治疗在内的不同治疗方法对头颈部鳞状细胞癌的治疗效果。
材料与方法
作者检索了所有电子数据库（Medline、Embase和Cochrane），查找1970年至2011年1月发表的所有文章。从文章中提取了评估治疗方法（化疗或放疗）的数据、患者数量、发表日期和作者姓名，并整理成表格。
结果
本研究纳入了46项研究。所有三种方法均显示，放疗后或放疗联合化疗可显著提高生存率（p值<0.01）。
结论
得出结论，在决定不进行手术治疗SCC后，推荐的治疗方案是同步放化疗。
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