Jia Hong-wei, Wang Bao-li, Kuang Chen-zhong
Department of Endocrinology, The General Hospital, Tianjin Medical University, Tianjin.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:116-9.
To study the therapeutic effects of Rhizoma Drynariae and estrogen on osteoporosis in ovariectomized (OVX) rats.
Fifty-five female rats were randomly divided into 5 groups, the normal control (normal),the sham operated (sham), the model, the estrogen, and the Rhizoma drynariae (RD) groups; ovariectomized rats were used as postmenopausal osteoporosis model. The changes of morphology and dynamic parameters in different groups were determined by bone histomorphometry.
Compared with the model group, the trabecular volume (TBV/TTV) , trabecular thickness (MTPT) and density (MTPD) in the other four groups were significantly increased, while the trabecular template spacing (MTPS) and the ratio of trabecular surface to trabecular volume (TBS/TBV) significantly decreased (P <0. 05); and the osteoid surface (TOS), single label surface [Sfract (s) ] ,double label surface [Sfract (d) ] and bone formation rate (Svf) also decreased,while osteoid maturation period (OMP) increased in the latter four groups. No significant difference of cortical width (MCW) was found between these 5 groups. Compared with the normal and sham groups, TOS, Sfract ( s) , Sfract ( d) , Svf in the estrogen and RD groups increased significantly, while OMP decreased; no significant difference was found in other parameters.
Rhizoma Drynariae has the similar effect with estrogen in maintaining normal trabecular structure and connection by inhibiting the increased bone turnover of postmenopausal osteoporosis.
研究骨碎补与雌激素对去卵巢（OVX）大鼠骨质疏松症的治疗作用。
将55只雌性大鼠随机分为5组，即正常对照组（正常组）、假手术组（假手术组）、模型组、雌激素组和骨碎补组；以去卵巢大鼠作为绝经后骨质疏松症模型。采用骨组织形态计量学方法测定不同组别的形态学和动力学参数变化。
与模型组相比，其他四组的骨小梁体积（TBV/TTV）、骨小梁厚度（MTPT）和密度（MTPD）均显著增加，而骨小梁模板间距（MTPS）和骨小梁表面与骨小梁体积之比（TBS/TBV）显著降低（P<0.05）；后四组的类骨质表面（TOS）、单标记表面[Sfract（s）]、双标记表面[Sfract（d）]和骨形成率（Svf）也降低，而类骨质成熟期（OMP）增加。这5组之间的皮质宽度（MCW）无显著差异。与正常组和假手术组相比，雌激素组和骨碎补组的TOS、Sfract（s）、Sfract（d）、Svf显著增加，而OMP降低；其他参数无显著差异。
骨碎补在维持正常骨小梁结构和连接方面与雌激素具有相似的作用，可抑制绝经后骨质疏松症骨转换增加。
