Perez C A, Lee F A, Ackerman L V, Ogura J H, Powers W E
AJR Am J Roentgenol. 1976 Feb;126(2):248-60. doi: 10.2214/ajr.126.2.248.
This is a non-randomized comparison of 98 patients with epidermoid carcinoma of the tonsil treated by preoperative irradiation and surgery and 97 patients receiving irradiation alone. Patients treated with preoperative irradiation received, in most instances, 3,000 rads tumor dose in three weeks through ipsilateral portals, followed within two to six weeks after completion of therapy by an en bloc tumor resection and radical neck dissection. The group treated with irradiation alone received tumor doses in the range of 5,500-6,500 rads in six weeks. No significant difference was noted in the survival yielded by either treatment modality. Both treatment modalities were equally effective in controlling the tumor in the metastatic ipsilateral lymph nodes. In selected cases, a combination of both modalitites may offer better results, but this remains to be proved.
这是一项对98例接受术前放疗及手术治疗的扁桃体表皮样癌患者与97例单纯接受放疗患者的非随机对照研究。接受术前放疗的患者多数情况下，通过同侧照射野在三周内给予3000拉德的肿瘤剂量，治疗结束后两至六周内行肿瘤整块切除及根治性颈清扫术。单纯放疗组在六周内接受5500 - 6500拉德的肿瘤剂量。两种治疗方式的生存率无显著差异。两种治疗方式在控制同侧转移淋巴结的肿瘤方面同样有效。在部分病例中，两种方式联合使用可能会取得更好的效果，但这仍有待证实。
