快速眼动睡眠行为障碍（RBD）可能是儿童发作性睡病的首发症状之一。
REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.
作者信息
Nevsimalova Sona, Prihodova Iva, Kemlink David, Lin Ling, Mignot Emmanuel
机构信息
Department of Neurology, 1st Medical Faculty, Charles University, Prague, Czech Republic.
出版信息
Sleep Med. 2007 Nov;8(7-8):784-6. doi: 10.1016/j.sleep.2006.11.018. Epub 2007 Jun 13.
More than one in three adult patients suffering from narcolepsy-cataplexy experience rapid eye movement (REM) behavior disorder (RBD), while RBD in childhood is extremely rare. We present the cases of two girls (aged 9 and 7 years old) with narcolepsy-cataplexy, in whom RBD was one of the first symptoms of the disease. The coincidence of RBD was seen by nocturnal video-polysomnography (v-PSG), and narcolepsy was diagnosed from short sleep latency and multiple sleep onset REMs (SOREMs) during a multiple sleep latency test (MSLT). Both girls were human leukocyte antigen (HLA)-DQB1 *0602 positive, and their cerebrospinal fluid (CSF) hypocretin level (Hcrt-1) was extremely low.
超过三分之一患有发作性睡病-猝倒症的成年患者会出现快速眼动（REM）睡眠行为障碍（RBD），而儿童期的RBD极为罕见。我们报告了两名患有发作性睡病-猝倒症的女孩（分别为9岁和7岁）的病例，其中RBD是该病的首发症状之一。通过夜间视频多导睡眠图（v-PSG）观察到RBD的存在，并在多次睡眠潜伏期试验（MSLT）中根据短睡眠潜伏期和多次睡眠起始快速眼动期（SOREMs）诊断为发作性睡病。两名女孩的人类白细胞抗原（HLA）-DQB1 *0602均为阳性，且其脑脊液（CSF）中下丘脑分泌素水平（Hcrt-1）极低。
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