儿童癌症幸存者对哌甲酯的急性神经认知反应：一项随机、双盲、交叉试验。
Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial.
作者信息
Conklin Heather M, Khan Raja B, Reddick Wilburn E, Helton Susan, Brown Ronald, Howard Scott C, Bonner Melanie, Christensen Robbin, Wu Shengjie, Xiong Xiaoping, Mulhern Raymond K
机构信息
St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
出版信息
J Pediatr Psychol. 2007 Oct;32(9):1127-39. doi: 10.1093/jpepsy/jsm045. Epub 2007 Jun 14.
OBJECTIVE
To investigate the acute efficacy and adverse side effects of methylphenidate (MPH) among survivors of childhood cancer [acute lymphoblastic leukemia (ALL) or brain tumor (BT)] with learning impairments.
METHODS
Participants (N = 122) completed a two-day, in-clinic, double-blind, cross-over trial during which they received MPH (0.60 mg/kg of body weight) and placebo that were randomized in administration order across participants. Performance was evaluated using measures of attention, memory, and academic achievement.
RESULTS
A significant MPH versus placebo effect was revealed on a measure of attention, cognitive flexibility, and processing speed (Stroop Word-Color Association Test). Male gender, older age at treatment, and higher intelligence were predictive of better medication response. No significant differences were found for number or severity of adverse side effects as a function of active medication.
CONCLUSIONS
MPH shows some neurocognitive benefit and is well tolerated by the majority of children surviving ALL and BT.
目的
探讨哌甲酯（MPH）对患有学习障碍的儿童癌症（急性淋巴细胞白血病（ALL）或脑肿瘤（BT））幸存者的急性疗效及不良反应。
方法
参与者（N = 122）完成了一项为期两天的门诊双盲交叉试验，在此期间他们接受了MPH（0.60毫克/千克体重）和安慰剂，给药顺序在参与者中随机分配。使用注意力、记忆力和学业成绩指标评估表现。
结果
在注意力、认知灵活性和处理速度测量（斯特鲁普文字-颜色联想测验）方面，MPH与安慰剂之间存在显著差异。男性、治疗时年龄较大和智商较高预示着药物反应更好。作为活性药物的函数，不良反应的数量或严重程度未发现显著差异。
结论
MPH显示出一定的神经认知益处，并且大多数ALL和BT幸存者儿童对其耐受性良好。
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