海洋生物学。佛罗里达红潮为囊性纤维化带来药物线索。
Marine biology. Florida red tide brews up drug lead for cystic fibrosis.
作者信息
Potera Carol
出版信息
Science. 2007 Jun 15;316(5831):1561-2. doi: 10.1126/science.316.5831.1561.
Abstract
Among the nasty compounds produced by the organism responsible for Florida’s red tides is one with some surprising properties
摘要
在引发佛罗里达赤潮的生物体所产生的有害化合物中，有一种具有一些惊人的特性。
相似文献
1
Marine biology. Florida red tide brews up drug lead for cystic fibrosis.海洋生物学。佛罗里达红潮为囊性纤维化带来药物线索。
Science. 2007 Jun 15;316(5831):1561-2. doi: 10.1126/science.316.5831.1561.
2
Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays.在钠通道受体结合试验中，短裸甲藻毒素（PbTx）抑制剂是一种天然的短裸甲藻毒素作用抑制剂。
Cell Mol Neurobiol. 2004 Aug;24(4):553-63. doi: 10.1023/b:cemn.0000023629.81595.09.
3
Airway responses to aerosolized brevetoxins in an animal model of asthma.哮喘动物模型中气道对雾化短裸甲藻毒素的反应。
Am J Respir Crit Care Med. 2005 Jan 1;171(1):26-34. doi: 10.1164/rccm.200406-735OC. Epub 2004 Sep 24.
4
Structure activity relationship of brevenal hydrazide derivatives.短裸甲藻毒素酰肼衍生物的构效关系
Mar Drugs. 2014 Mar 28;12(4):1839-58. doi: 10.3390/md12041839.
5
Sublethal red tide toxin exposure in free-ranging manatees (Trichechus manatus) affects the immune system through reduced lymphocyte proliferation responses, inflammation, and oxidative stress.在自由放养的海牛（西印度海牛）中，亚致死剂量的赤潮毒素暴露会通过降低淋巴细胞增殖反应、引发炎症和氧化应激来影响免疫系统。
Aquat Toxicol. 2015 Apr;161:73-84. doi: 10.1016/j.aquatox.2015.01.019. Epub 2015 Jan 22.
6
Effects of brevetoxins on murine myeloma SP2/O cells: aberrant cellular division.短裸甲藻毒素对小鼠骨髓瘤SP2/O细胞的影响：异常细胞分裂。
Int J Toxicol. 2003 Mar-Apr;22(2):73-80. doi: 10.1080/10915810305095.
7
Aerosolized red-tide toxins (brevetoxins) and asthma.气溶胶化的赤潮毒素（短裸甲藻毒素）与哮喘
Chest. 2007 Jan;131(1):187-94. doi: 10.1378/chest.06-1830.
8
Effect of amiloride and saline on nasal mucociliary clearance and potential difference in cystic fibrosis and normal subjects.氨氯吡咪和生理盐水对囊性纤维化患者及正常受试者鼻黏膜纤毛清除功能和电位差的影响。
Thorax. 1993 Aug;48(8):812-6. doi: 10.1136/thx.48.8.812.
9
Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis.囊性纤维化气道上皮中盐和水的药理调节。
Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 2):S65-9. doi: 10.1164/ajrccm/151.3_Pt_2.S65.
10
Susceptibility of gametes and embryos of the eastern oyster, Crassostrea virginica, to Karenia brevis and its toxins.美国东牡蛎（Crassostrea virginica）的配子和胚胎对短裸甲藻（Karenia brevis）及其毒素的敏感性。
Toxicon. 2015 Jun 1;99:6-15. doi: 10.1016/j.toxicon.2015.03.002. Epub 2015 Mar 12.
引用本文的文献
1
: The biology and ecology of a toxic genus.一个有毒属的生物学与生态学
Harmful Algae. 2012 Feb;14:156-178. doi: 10.1016/j.hal.2011.10.020. Epub 2011 Oct 25.
2
Recent progress in neuroactive marine natural products.海洋天然产物的神经活性研究进展。
Nat Prod Rep. 2014 Jan 17;31(2):273-309. doi: 10.1039/c3np70083f.
3
The Art of Red Tide Science.赤潮科学的艺术。
Harmful Algae. 2012 May 1;17:1-5. doi: 10.1016/j.hal.2012.02.002.
4
Total synthesis of brevenal.布雷文那的全合成。
J Am Chem Soc. 2011 Mar 9;133(9):3208-16. doi: 10.1021/ja200089f. Epub 2011 Feb 15.
5
Review of Florida Red Tide and Human Health Effects.佛罗里达赤潮及其对人类健康影响的综述。
Harmful Algae. 2011 Jan 1;10(2):224-233. doi: 10.1016/j.hal.2010.08.006.
Zotero 插件