Yoo Changhoon, Ryu Min-Hee, Huh Jooryung, Park Ji Hyun, Kang Hye Jin, Ahn Hyo Sook, Lee Yongjae, Kim Myoung Joon, Lee Hyoungnam, Kim Tae Won, Chang Heung Moon, Lee Jae-Lyun, Kang Yoon-Koo
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Am J Hematol. 2007 Sep;82(9):821-3. doi: 10.1002/ajh.20962.
Ocular adnexal lymphoma (OAL) is a mostly extranodal marginal zone lymphoma (EMZL). Recent findings have suggested an association between Chlamydia psittaci (Cp) infection and OAL. We sought to confirm this issue and to analyze the clinicopathologic characteristics of OAL in Korea. Between 1993 and 2004, 33 OAL cases were identified at the Asan Medical Center, Seoul, Korea. DNA was extracted from paraffin-embedded tissues, and touchdown enzyme time release polymerase chain reaction was performed to identify three Chlamydia species (Cp, C. tracomatis, and C. pneumoniae). The same procedures were also performed in 21 samples from patients with non-neoplastic ocular adnexal disease (NNOAD). All OAL cases were EMZL. Cp DNA was detected in 26/33 (79%) OAL samples compared with 5/21 (23%) NNOAD samples (P < 0.001). With a median follow-up of 38.5 months (range: 1-105 months), the 5-year progression-free survival (PFS) and overall survival (OS) rates of OAL patients were 72% and 93%, respectively. Clinicopathologic characteristics, recurrence rate, PFS, and OS were not associated with Cp infection. Our study demonstrates an association between OAL and Cp infection in Korea, suggesting that Cp plays a role as a causative antigen in Korean OAL patients.
眼附属器淋巴瘤（OAL）大多是结外边缘区淋巴瘤（EMZL）。最近的研究结果提示鹦鹉热衣原体（Cp）感染与OAL之间存在关联。我们试图证实这一问题，并分析韩国OAL的临床病理特征。1993年至2004年期间，韩国首尔峨山医疗中心共确诊33例OAL病例。从石蜡包埋组织中提取DNA，采用降落酶时间释放聚合酶链反应来鉴定三种衣原体（Cp、沙眼衣原体和肺炎衣原体）。对21例非肿瘤性眼附属器疾病（NNOAD）患者的样本也进行了同样的操作。所有OAL病例均为EMZL。在33例OAL样本中有26例（79%）检测到Cp DNA，相比之下，21例NNOAD样本中有5例（23%）检测到Cp DNA（P<0.001）。中位随访时间为38.5个月（范围：1 - 105个月），OAL患者的5年无进展生存率（PFS）和总生存率（OS）分别为72%和93%。临床病理特征、复发率、PFS和OS与Cp感染无关。我们的研究证实了韩国OAL与Cp感染之间存在关联，表明Cp在韩国OAL患者中作为致病抗原发挥作用。
