Fehr Thorsten, Wiedenmann Patrick, Herrmann Manfred
Institute for Cognitive Neuroscience, Department of Neuropsychology/Behavioral Neurobiology, University of Bremen, Germany.
Int J Psychophysiol. 2007 Sep;65(3):284-93. doi: 10.1016/j.ijpsycho.2007.05.006. Epub 2007 May 21.
The concept of a specific memory network that drives addictive behavior has often been discussed in relation to the phenomenon of sudden relapse into addiction after years of abstinence. But there is still a lack of data that shows a link between drug-related cue processing and specific changes of behavior in addicts. In the present study we investigated the relationship between smoking-related picture processing, performance in a color matching task, and ERP topographies. Fifteen smokers and 19 non-smoking participants performed a color matching task including monochromic pictures with smoking-related and neutral content. Smokers and non-smokers showed remarkable differences between stimulus category-related ERP topographies. Furthermore, both smokers and non-smokers showed increased reaction times during color matching when the picture contents were related to smoking behavior. The results are discussed with respect to different drug-cue-related patterns of information processing in smokers and non-smokers.
驱动成瘾行为的特定记忆网络这一概念，常常与多年禁欲后突然复吸成瘾的现象相关联进行讨论。但仍缺乏数据表明药物相关线索处理与成瘾者行为的特定变化之间存在联系。在本研究中，我们调查了吸烟相关图片处理、颜色匹配任务表现与事件相关电位（ERP）地形图之间的关系。15名吸烟者和19名非吸烟参与者进行了一项颜色匹配任务，其中包括带有吸烟相关和中性内容的单色图片。吸烟者和非吸烟者在刺激类别相关的ERP地形图上表现出显著差异。此外，当图片内容与吸烟行为相关时，吸烟者和非吸烟者在颜色匹配过程中的反应时间均增加。针对吸烟者和非吸烟者中不同的药物线索相关信息处理模式对结果进行了讨论。
