大鼠基底外侧杏仁核中与年龄相关的树突肥大和性别差异
Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala.
作者信息
Rubinow Marisa J, Drogos Lauren L, Juraska Janice M
机构信息
Department of Psychology, University of Illinois at Urbana-Champaign, 603 E. Daniel Street, Champaign, IL 61820, USA.
出版信息
Neurobiol Aging. 2009 Jan;30(1):137-46. doi: 10.1016/j.neurobiolaging.2007.05.006. Epub 2007 Jun 14.
Abstract
Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.
摘要
很少有研究探讨衰老或性别对基底外侧杏仁核解剖学指标的影响。我们对年轻成年（3 - 5个月）和老年（20 - 24个月）雄性和雌性Long-Evans大鼠基底外侧核的高尔基-考克斯染色组织中的棘密度和树突物质进行了量化。在主要神经元中测量了树突分支和棘密度。年龄而非性别影响了树突结构，老年动物显示出明显更多的树突物质。我们实验室之前在同一组实验对象中的研究结果表明，衰老对内侧前额叶皮质和海马体中的树突物质有相反的影响。我们在此还报告了不同年龄段之间在树突棘密度上的性别差异，男性更具优势。
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