Faye Babacar, Ndiaye Jean-Louis, Ndiaye Daouda, Dieng Yemou, Faye Oumar, Gaye Oumar
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Pharmacie et Odontologie, Université Cheikh Anta Diop, Dakar, Senegal.
Malar J. 2007 Jun 14;6:80. doi: 10.1186/1475-2875-6-80.
In view of the high level of chloroquine resistance in many countries, WHO has recommended the use of combination therapy with artemisinin derivatives in the treatment of uncomplicated malaria due to Plasmodium falciparum. Four antimalarial drug combinations, artesunate plus amodiaquine (Arsucam), artesunate plus mefloquine (Artequin), artemether plus lumefantrine (Coartem; four doses and six doses), and amodiaquine plus sulphadoxine-pyrimethamine, were studied in five health districts in Senegal.
This is a descriptive, analytical, open, randomized study to evaluate the efficacy and tolerability of these four antimalarial combinations in the treatment of uncomplicated falciparum malaria using the 2002 WHO protocol.
All drug combinations demonstrated good efficacy. On day 28, all combinations resulted in an excellent clinical and parasitological response rate of 100% after correction for PCR results, except for the four-dose artemether-lumefantrine regimen (96.4%). Follow-up of approximately 10% of each treatment group on day 42 demonstrated an efficacy of 100%.The combinations were well tolerated clinically and biologically. No unexpected side-effect was observed and all side-effects disappeared at the end of treatment. No serious side-effect requiring premature termination of treatment was observed.
The four combinations are effective and well-tolerated.
鉴于许多国家氯喹耐药性水平较高，世界卫生组织已建议使用青蒿素衍生物联合疗法治疗由恶性疟原虫引起的非复杂性疟疾。在塞内加尔的五个卫生区对四种抗疟药物组合进行了研究，即青蒿琥酯加阿莫地喹（Arsucam）、青蒿琥酯加甲氟喹（Artequin）、蒿甲醚加本芴醇（Coartem；四剂和六剂）以及阿莫地喹加磺胺多辛-乙胺嘧啶。
这是一项描述性、分析性、开放性随机研究，采用2002年世界卫生组织方案评估这四种抗疟组合治疗非复杂性恶性疟的疗效和耐受性。
所有药物组合均显示出良好疗效。在第28天，除四剂蒿甲醚-本芴醇治疗方案（96.4%）外，校正PCR结果后所有组合的临床和寄生虫学反应率均达到100%的优异水平。在第42天对每个治疗组约10%的患者进行随访显示疗效为100%。这些组合在临床和生物学上耐受性良好。未观察到意外副作用，且所有副作用在治疗结束时均消失。未观察到需要提前终止治疗的严重副作用。
这四种组合有效且耐受性良好。
